Mission:

The National NeuroAIDS Tissue Consortium (NNTC), funded by NIMH and NINDS, was established in 1998 to collect, store, and distribute samples of central and peripheral nervous system tissue, cerebrospinal fluid, blood, and other organs such as heart, lung, liver, and kidney collected from HIV positive and negative patients, to support researchers around the world who wish to pursue sound research projects and further our knowledge of NeuroAIDS disorders. The Consortium’s unique contribution to brain banking and NeuroAIDS in general is its high quality and well characterized specimens. Extensive efforts are taken to collect comprehensive neuromedical, neuropsychological, and psychiatric data prior to death. Detailed pathological evaluations of brain, spinal cord, and peripheral organs are conducted post-mortem and samples are then banked according to strict established protocols to ensure uniformity across the four clinical sites. The resource has supported close to 500 requests to date and has resulted in more than 500 publications both from internal and external investigators. If you are a scientist interested in utilizing our resource, you can browse our repositories with the Query Tool, and learn how to request samples on the Requests page.

Current Cohort: As of March 15, 2019, 3,178 participants have enrolled into the clinical evaluation/tissue donation program and 2,195 individuals have donated CNS material to the bank. The Consortium is actively following 606 HIV+ individuals and 30 HIV- individuals at four clinical sites across the US.

Please refer to our COHORT REPORTS PowerPoint presentation for more complete details.

Suppresion Cohort: As of March 15, 2019, 219 participants have been classified as virally suppressed according to the criteria listed here. These participants include 56 with CNS specimens and other autopsy specimens collected.

Please refer to our SUPPRESSION COHORT REPORTS PowerPoint presentation for more complete details.

 

 

Virally Suppressed Cases (57)

HIV+ deceased individuals on ARV treatment with viral suppresssion with tissues and biofluids available for study.

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Publications

Zyskind, Jacob W et. al. (2015) E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity. - J Neurochem

Valdebenito, Silvana et. al. (2018) The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis. - Int J Mol Sci

C Carey et. al. (2004) Initial validation of a screening battery for the detection of HIV-associated cognitive impairment - The Clinical Neuropsychologist

Steven P Woods et. al. (2007) Frequency and predictors of self-reported prospective memory complaints in individuals infected with HIV - Archives of Clinical Neuropsychology: The Official Journal of the National Academy of Neuropsychologists