Mission:

The National NeuroAIDS Tissue Consortium (NNTC), funded by NIMH and NINDS, was established in 1998 to collect, store, and distribute samples of central and peripheral nervous system tissue, cerebrospinal fluid, blood, and other organs such as heart, lung, liver, and kidney collected from HIV positive and negative patients, to support researchers around the world who wish to pursue sound research projects and further our knowledge of NeuroAIDS disorders. The Consortium’s unique contribution to brain banking and NeuroAIDS in general is its high quality and well characterized specimens. Extensive efforts are taken to collect comprehensive neuromedical, neuropsychological, and psychiatric data prior to death. Detailed pathological evaluations of brain, spinal cord, and peripheral organs are conducted post-mortem and samples are then banked according to strict established protocols to ensure uniformity across the four clinical sites. The resource has supported close to 500 requests to date and has resulted in more than 500 publications both from internal and external investigators. If you are a scientist interested in utilizing our resource, you can browse our repositories with the Query Tool, and learn how to request samples on the Requests page.

Current Cohort: As of October 20, 2017, 3,088 participants have enrolled into the clinical evaluation/tissue donation program and 2,139 individuals have donated CNS material to the bank. The Consortium is actively following 600 HIV+ individuals and 31 HIV- individuals at four clinical sites across the US.

Please refer to our COHORT REPORTS PowerPoint presentation for more complete details.

 

 

 

 

 

Virally Suppressed Cases (56)

HIV+ deceased individuals on ARV treatment with viral suppresssion with tissues and biofluids available for study.

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Publications

Nitkiewicz, Jadwiga et. al. (2017) HIV induces expression of complement component C3 in astrocytes by NF-ΚB-dependent activation of interleukin-6 synthesis - Journal of Neuroinflammation

B. Becker, Alyssa et. al. (2017) Heart and Nervous System Pathology in Compound Heterozygous Friedreich Ataxia - Journal of Neuropathology & Experimental Neurology

Jessica Robinson-Papp et. al. (2017) The Use of Visual Rating Scales to Quantify Brain MRI Lesions in Patients with HIV Infection. - J Neuroimaging

Var, S. R. et. al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use - AIDS