The National NeuroAIDS Tissue Consortium (NNTC), funded by NIMH and NINDS, was established in 1998 to collect, store, and distribute samples of central and peripheral nervous system tissue, cerebrospinal fluid, blood, and other organs such as heart, lung, liver, and kidney collected from HIV positive and negative patients, to support researchers around the world who wish to pursue sound research projects and further our knowledge of NeuroAIDS disorders. The Consortium’s unique contribution to brain banking and NeuroAIDS in general is its high quality and well characterized specimens. Extensive efforts are taken to collect comprehensive neuromedical, neuropsychological, and psychiatric data prior to death. Detailed pathological evaluations of brain, spinal cord, and peripheral organs are conducted post-mortem and samples are then banked according to strict established protocols to ensure uniformity across the four clinical sites. The resource has supported close to 500 requests to date and has resulted in more than 500 publications both from internal and external investigators. If you are a scientist interested in utilizing our resource, you can browse our repositories with the Query Tool, and learn how to request samples on the Requests page.

Current Cohort: As of June 25, 2018, 3,121 participants have enrolled into the clinical evaluation/tissue donation program and 2,166 individuals have donated CNS material to the bank. The Consortium is actively following 592 HIV+ individuals and 30 HIV- individuals at four clinical sites across the US.

Please refer to our COHORT REPORTS PowerPoint presentation for more complete details.






Virally Suppressed Cases (57)

HIV+ deceased individuals on ARV treatment with viral suppresssion with tissues and biofluids available for study.

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Singer, Elyse J et. al. (2017) The Persistence of HIV-Associated Neurocognitive Disorder (HAND) in the Era of Combined Antiretroviral Therapy (cART) - Global Virology II - HIV and NeuroAIDS

Rose, Rebecca et. al. (2018) Eradication of HIV from Tissue Reservoirs: Challenges for the Cure. - AIDS Res Hum Retroviruses

Lamers, Susanna L et. al. (2018) Brain-specific HIV Nef identified in multiple patients with neurological disease. - J Neurovirol

Nolan, David J et. al. (2018) The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy. - AIDS Res Hum Retroviruses