The National NeuroAIDS Tissue Consortium (NNTC), funded by NIMH and NINDS, was established in 1998 to collect, store, and distribute samples of central and peripheral nervous system tissue, cerebrospinal fluid, blood, and other organs such as heart, lung, liver, and kidney collected from HIV positive and negative patients, to support researchers around the world who wish to pursue sound research projects and further our knowledge of NeuroAIDS disorders. The Consortium’s unique contribution to brain banking and NeuroAIDS in general is its high quality and well characterized specimens. Extensive efforts are taken to collect comprehensive neuromedical, neuropsychological, and psychiatric data prior to death. Detailed pathological evaluations of brain, spinal cord, and peripheral organs are conducted post-mortem and samples are then banked according to strict established protocols to ensure uniformity across the four clinical sites. The resource has supported close to 500 requests to date and has resulted in more than 500 publications both from internal and external investigators. If you are a scientist interested in utilizing our resource, you can browse our repositories with the Query Tool, and learn how to request samples on the Requests page.

Current Cohort: As of June 21, 2016, 2,975 participants have enrolled into the clinical evaluation/tissue donation program and 2,048 individuals have donated CNS material to the bank. The Consortium is actively following 573 HIV+ individuals and 29 HIV- individuals at four clinical sites across the US.

Please refer to our COHORT REPORTS PowerPoint presentation for more complete details.






Virally Suppressed Cases (45)

HIV+ deceased individuals on ARV treatment with viral suppresssion with tissues and biofluids available for study.

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Grant Deadlines

AIDS grant deadlines are coming up. A reminder that if you intend to submit an NNTC Request Application in preparation for a grant, please do so within 20 business days of your planned grant...Read More


Lucas, C.H. et. al. (2014) Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND) - Neuroscience Letters

Commins, D.L. et. al. (2005) Immunohistochemistry of the nervous system - Molecular Morphology and Immunomicroscopy

Ryan, E., Byrd, D. et. al. (2007) Neuropsychological Evaluation - Comprehensive Textbook of AIDS Psychiatry

Pottiez, G. et. al. (2010) Metabolomics and Proteomics - The Neurology of AIDS