Virally Suppressed Cases

A Unique resource available for HIV eradication research

Research toward a cure for HIV is one of the high priority topics of the NIH (NOT-OD-15-137). To effect a cure, reservoirs in which HIV persists despite treatment need to be identified and studied. However obtaining tissue for this work is challenging and for many organs is not possible. The National NeuroAIDS Tissue Consortium (NNTC, supported by NIMH and NINDS) represents a unique resource for such tissue. Subjects are studied longitudinally and donate biofluids (blood and cerebrospinal fluid) and agree to tissue donation upon death. While a distinct focus of the NNTC is the nervous system (and the brain is one potential reservoir), in addition to the brain and peripheral nervous system tissue other organs are collected at autopsy, including lymph nodes, heart, lung, liver, testes and more.

Of the over 900 autopsies in the NNTC tissue bank, we have identified 57 cases of subjects on antiretroviral treatment with viral suppression that show exceptional utility for HIV eradication research. We have reserved tissue and biofluids from these cases for allocation to investigators performing well-justified eradication research. Detailed information about these cases can be found below and forms for requesting tissue or fluids can be found here (nntc.org/content/requests).

The NNTC steering committee developed two different criteria to identify these cases, depending on the length of known suppression, and allowing for differences in the number and timing of viral load determinations before death in subjects on study.

Criteria 1. The subjects have been followed for at least 5 years before death. There must be at least 1 undetectable viral load within 1 year of death, or 2 undetectable viral loads within 2 years of death. Over the 5 year period before death, there must be at least 4 undetectable viral loads. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 5 year period.

Criteria 2. The subjects have been followed for at least 2 years before death.  There must be at least 1 undetectable viral load within 6 months of death. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 2 year period.

25 cases met the first set of criteria, and 50 met the second. Of these, 18 cases met both sets of criteria. Investigators are of course welcome to examine the data and develop their own criteria, as well as ask us for assistance in identifying cases meeting their criteria. Furthermore, using our search tool (nntc.org/query/tool) tissue from our many other HIV+ subjects, as well as from HIV- controls can be requested.

There are a total of 57 cases that meet all criteria
This reflects 1.8% of the total cohort of 3,128 cases
Case IDSuppression CriteriaCriteria defined by the NNTC to classify deceased participants as virally suppressed. Currently we have used two criteria and the details are noted above in the cohort description.Last viral loadLast viral load measure yearDays between last viral load and deathNadir CD4 countDays between nadir CD4 and deathLast CD4 countDays between CD4 measure and deathHighest viral load measureDays between highest viral load and deathARVs reported as currentCurrent ARV medication regimen at last assessmentLast ARV report yearYear of last ARV medication assessmentViral load at last ARV reportYear of viral load at last ARV reportLength of time on studyYearsAvailable autopsy specimensPlasma Collections Available# of unique collections of plasma where a sample is reported to be availableLast plasma collection yearYear of last collection of plasma where a sample is reported to be availablePBMCS collections available# of unique collections of PBMCs where a sample is reported to be availableLast PBMC collection yearYear of last collection of PBMCs where a sample is reported to be availableCSF collections available# of unique collections of CSF where a sample is reported to be availableLast CSF collection yearYear of last collection of CSF where a sample is reported to be availableUrine collections available# of unique collections of urine where a sample is reported to be availableLast urine collection yearYear of last collection of urine where a sample is reported to be availableSerum collections available# of unique collections of serum where a sample is reported to be availableLast serum collection yearYear of last collection of serum where a sample is reported to be availableStart yearParticipant's enrollment date into the NNTC cohortDeceased yearParticipant's year of deathEndo/Exo-Chemical dataAvailability of endo/exo-chemical data from previous research on caseMorphometric dataAvailability of morphometric data from previous research on caseGene Expression dataAvailability of genotype data from previous research on caseGenotype dataAvailability of genotype data from previous research on caseProtein dataAvailability of protein data from previous research on caseHIV StatusGenderRaceOther study dataAvailability of other data from previous research on caseEthnicityCurrent statusParticipant's current status in the studyAge Interval at Last VisitIf active, age is based on last clinical visit or relative to today if no visit information is available. If inactive, age is based on date of inactive status. If deceased, age is based on date of death.# of clinic visits on studyYears with HIV
00006Criteria 1, Criteria 2<50200999205484392996711177.5Fixed Brain, Frozen Brain, Spinal Cord10200910200942006420087200920032009YesYesYesHIV+FemaleBlackNot HispanicDeceased with autopsy50-645-10 visits16 or more years
00009Criteria 2<50201011318820367911131402412744ATV; atazanavir (Reyataz), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2010<5020106Fixed Brain, Frozen Brain, Spinal Cord1320101320102200412201011201020032010YesYesHIV+FemaleWhiteNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00068Criteria 1, Criteria 2<40020061990249523919<400193TC; lamivudine (Epivir), ABC; abacavir (Ziagen), NVP; nevirapine (Viramune)2006<40020066Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel5200612006320034200619992006YesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits16 or more years
00155Criteria 21402012512143142435186633517ATR; efavirenz 600mg + emtricitabine 200mg + tenofivir DF 300mg (Atripla)2010<4020109Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, 37, 3832010120021200220022012HIV+MaleWhiteHispanicDeceased with autopsy35-492-4 visits11-15 years
00522Criteria 1<502008360172547465456<400456ABC; abacavir (Ziagen), EFV; efavirenz (Sustiva), KTA; lopinavir/ritonavir (Kaletra)2008<5020088Fixed Brain, Frozen Brain, Pituitary Gland, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel13200812200812200812200813200820002009YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+1 visit16 or more years
00571Criteria 1, Criteria 2<5020053819112845938<5038.6Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes13200511200512200519992005YesYesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00574Criteria 1, Criteria 2<5020142075802741137>7500006298EPZ; ziagen + epivir (Epzicom), FPV; fosamprenavir (Lexiva), RTV; ritonavir (Norvir)2014<50201415Fixed Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes3320143220149201432201425201419992014YesYesYesHIV+MaleBlackNot HispanicDeceased with autopsy65+>10 visits16 or more years
00590Criteria 2<502002777217772177<50773TC; lamivudine (Epivir), NVP; nevirapine (Viramune)2002<5020023Fixed Brain5200252002520025200219992002YesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits6-10 years
00599Criteria 1, Criteria 2<5020155565202227455103360263TC; lamivudine (Epivir), ABC; abacavir (Ziagen), RGV; raltegravir (Isentress)2015<50201516Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Testes3620153320154201531201324201519992015YesHIV+MaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00616Criteria 2<5020061461252005537146287011774CBV; zidovudine + lamivudine (Combivir), EFV; efavirenz (Sustiva)2006<5020067Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung1220061020061020063200619992007YesYesYesYesYesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-64>10 visits11-15 years
00630Criteria 1, Criteria 2<50200615718260927120<50157CBV; zidovudine + lamivudine (Combivir), NFV; nelfinavir (Viracept)2006<5020066Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes1120061120061020061120052200620002006YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits11-15 years
00632Criteria 2652005346616413634211571980.5Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes1020057200562005820042200520002005YesYesHIV+MaleWhiteYesHispanicDeceased with autopsy50-645-10 visits11-15 years
00641Criteria 1, Criteria 2<502014276259213330>7500002660ATV; atazanavir (Reyataz), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2014<50201414Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes212013192013520077200716201320002014YesYesYesHIV+MaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00658Criteria 1, Criteria 2<502007747827825709752382ATR; efavirenz 600mg + emtricitabine 200mg + tenofivir DF 300mg (Atripla)2007<5020077Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes11200710200742004820065200720002008YesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00691Criteria 2<5020097638428241047765313613373TC; lamivudine (Epivir), EFV; efavirenz (Sustiva), TFV, PMPA; tenofivir DF (Viread)2009<5020096Fixed Brain, Frozen Brain, Spinal Cord1120099200812003120036200920022009YesYesYesHIV+FemaleBlackYesNot HispanicDeceased with autopsy35-49>10 visits11-15 years
00697Criteria 2<5020041303188567981303271131ABC; abacavir (Ziagen)2004<5020042Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes32004220041200320032005YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+2-4 visits6-10 years
00699Criteria 1, Criteria 2<502010180312113149118759526083TC; lamivudine (Epivir), ABC; abacavir (Ziagen), EFV; efavirenz (Sustiva)2010<5020108Fixed Brain, Frozen Brain, Spinal Cord17201015201012201012201020032011YesYesHIV+MaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00703Criteria 1, Criteria 2<502013103543883140103383338833TC; lamivudine (Epivir), EFV; efavirenz (Sustiva), TFV, PMPA; tenofivir DF (Viread)2013<50201310Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes2520132120135200517201221201320032014YesHIV+MaleMulti-racialNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00704Criteria 1, Criteria 2<502009149128149128149963070CBV; zidovudine + lamivudine (Combivir)2009<5020096Fixed Brain, Frozen Brain, Spinal Cord11200992009720098200920032009YesHIV+FemaleBlackHispanicDeceased with autopsy50-64>10 visits16 or more years
00719Criteria 2<50200152880821957245900808.2Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Testes4200142001420011199919992001YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy35-495-10 visits6-10 years
00739Criteria 2<50200392230866383126<50923TC; lamivudine (Epivir), d4T; stavudine (Zerit), EFV; efavirenz (Sustiva)2003<5020033Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes72003120034200220002003YesHIV+MaleWhiteYesHispanicDeceased with autopsy50-645-10 visits11-15 years
00865Criteria 1, Criteria 2<502005177133695785177266681986ABC; abacavir (Ziagen), d4T; stavudine (Zerit), EFV; efavirenz (Sustiva), SQV2 or FTV; saquinavir-sgc (Fortovase), NFV; nelfinavir (Viracept)2005<5020055Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, 27, 28, 29, 30, 31, 32, 34, 35122005820041020059200520002006YesYesHIV+MaleWhiteNot HispanicDeceased with autopsy35-49No ante-mortem visit16 or more years
00927Criteria 2<5020071573387567157573008533TC; lamivudine (Epivir), ABC; abacavir (Ziagen), ATR; efavirenz 600mg + emtricitabine 200mg + tenofivir DF 300mg (Atripla), ATV; atazanavir (Reyataz), EFV; efavirenz (Sustiva), FTC; emtricitabine (Coviracil; Emtriva), RTV; ritonavir (Norvir), TFV, PMPA; tenofivir DF (Viread)2007<5020075Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, 27, 28, 29, 30, 31, 32, 34, 3592007520078200720022007YesHIV+MaleBlackNot HispanicDeceased with autopsy35-49No ante-mortem visit6-10 years
00946Criteria 2<4020144829439643048<4003555DRV; TMC-114, darunavir (Prezista), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2014<40201411Fixed Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, 28, 29, 30, 31, 32, 34, 35, 381420143201210201412201420022014YesHIV+MaleWhiteNot HispanicDeceased with autopsy65+2-4 visits11-15 years
00965Criteria 2<502006113754042381113<4006513TC; lamivudine (Epivir), ATV; atazanavir (Reyataz), DLV; delaviridine (Rescriptor), TFV, PMPA; tenofivir DF (Viread)2006<5020063Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, 27, 28, 29, 30, 31, 32, 34, 357200622005620067200620032006YesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64No ante-mortem visit11-15 years
01305Criteria 2<4002005180114247324618010031145ABC; abacavir (Ziagen), FPV; fosamprenavir (Lexiva), FTC; emtricitabine (Coviracil; Emtriva), NVP; nevirapine (Viramune), RTV; ritonavir (Norvir), TFV, PMPA; tenofivir DF (Viread)2005<40020053Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, 27, 28, 29, 30, 31, 32, 34, 35, 3862005220034200520032006YesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy35-49No ante-mortem visit16 or more years
01374Criteria 28520114826418491218<4002639.12Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel6201122011320043200419992012YesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01396Criteria 1, Criteria 24020108173170698179536473TC; lamivudine (Epivir), RTV; ritonavir (Norvir), SQV; saquinavir (Invirase), TFV, PMPA; tenofivir DF (Viread)201040201010Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel132010520093200712201020002011HIV+MaleWhiteNot HispanicDeceased with autopsy50-64>10 visits16 or more years
01410Criteria 2<5020091321428872671323509624133TC; lamivudine (Epivir), ABC; abacavir (Ziagen), FPV; fosamprenavir (Lexiva), RTV; ritonavir (Norvir)2009<5020096Fixed Brain, Frozen Brain, Spinal Cord142009132009420086200710200920032010YesYesYesYesHIV+FemaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
01495Criteria 24020090172058112671859832058DRV; TMC-114, darunavir (Prezista), KTA; lopinavir/ritonavir (Kaletra), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2009<4020095Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, 37, 38, 40320093200920042009HIV+MaleBlackNot HispanicDeceased with autopsy35-495-10 visits11-15 years
01565Criteria 2<40020069315194021393<40093.2Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Lymph Node, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, 37, 3822006120062200520042006YesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-642-4 visits11-15 years
01731Criteria 2<502009163217212368017216991312923TC; lamivudine (Epivir), ATV; atazanavir (Reyataz), RTV; ritonavir (Norvir), TFV, PMPA; tenofivir DF (Viread)2009<5020094Fixed Brain, Frozen Brain, Spinal Cord62009620094200920052009HIV+FemaleBlackHispanicDeceased with autopsy50-645-10 visits16 or more years
01806Criteria 18820103296650066500<4001547d4T; stavudine (Zerit), DRV; TMC-114, darunavir (Prezista), RGV; raltegravir (Isentress), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)20108820105Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung72010720108201120052011HIV+MaleWhiteNot HispanicDeceased with autopsy50-642-4 visits16 or more years
01866Criteria 2139200846641669117212932414143TC; lamivudine (Epivir), ATV; atazanavir (Reyataz), RTV; ritonavir (Norvir), TFV, PMPA; tenofivir DF (Viread)20085320083Fixed Brain, Frozen Brain, Spinal Cord720087200812005520085200820052009YesYesHIV+MaleBlackNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01878Criteria 1<5020112009954913320050200NVP; nevirapine (Viramune), TRU; emtricitabine + tenofovir (Truvada)2011<5020116Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes920118201142007820107201120052012YesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01986Criteria 1, Criteria 2202015303040123553032222911ATV; atazanavir (Reyataz), EPZ; ziagen + epivir (Epzicom), RTV; ritonavir (Norvir)2013<4020139Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Lymph Node, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Thymus, Kidney, Lung, Bowel, 37, 389201392013320087201320062015HIV+MaleWhiteNot HispanicDeceased with autopsy65+5-10 visits16 or more years
02035Criteria 1, Criteria 220201513825303030013839742328ATV; atazanavir (Reyataz), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)20142020149Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel1020141020151201510201411201520062015HIV+MaleUnknownHispanicDeceased with autopsy50-645-10 visits16 or more years
02087Criteria 1<502011552184752223552124752RGV; raltegravir (Isentress), TMC; TMC-125, etravirine (Intelence), TRU; emtricitabine + tenofovir (Truvada)2011<5020116Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes820118201112006820118201120062012YesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02104Criteria 248201014611561143028301941DRV; TMC-114, darunavir (Prezista), RGV; raltegravir (Isentress), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2009<4020093Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, 37, 3822009220092200920062010YesHIV+MaleWhiteYesHispanicDeceased with autopsy35-492-4 visits16 or more years
02122Criteria 2<502009134360918518506138521106KTA; lopinavir/ritonavir (Kaletra), TRU; emtricitabine + tenofovir (Truvada)2009<5020092Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Muscle, Heart, Kidney, Lung12007120091200920072009YesHIV+MaleBlackNot HispanicDeceased with autopsy50-642-4 visits16 or more years
02161Criteria 12020162743175046681126182709DTG; dolutegravir (Tivicay), TRU; emtricitabine + tenofovir (Truvada)201620201610Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, 27, 28, 29, 30, 31, 33, 341120161020159201611201620072017HIV+MaleBlackNot HispanicDeceased with autopsy65+5-10 visits16 or more years
02206Criteria 2<50201775325110374775694142280ATV; atazanavir (Reyataz), DTG; dolutegravir (Tivicay), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)2017<5020179Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, 27, 28, 29, 30, 31, 32, 33, 34, 35, 38112017122017120078201711201720072017HIV+FemaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
02225Criteria 2402010016118161983135962RGV; raltegravir (Isentress), TRU; emtricitabine + tenofovir (Truvada)2010<4020103Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, 37, 3842010320103201020072010HIV+FemaleWhiteHispanicDeceased with autopsy50-642-4 visits6-10 years
02235Criteria 2<5020141623244977493162103881296DRV; TMC-114, darunavir (Prezista), EPZ; ziagen + epivir (Epzicom), RGV; raltegravir (Isentress), RTV; ritonavir (Norvir)2014<5020147Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung11201411201411201420072015YesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-64>10 visits16 or more years
02252Criteria 2<502010133812278425133390002278ATR; efavirenz 600mg + emtricitabine 200mg + tenofivir DF 300mg (Atripla)2010<5020102Fixed Brain, Frozen Brain, Spinal Cord3201032010320103201020072010YesYesHIV+FemaleBlackNot HispanicDeceased with autopsy35-492-4 visits11-15 years
02300Criteria 1<402015192362127294192>1000003082ABC; abacavir (Ziagen), KTA; lopinavir/ritonavir (Kaletra), RGV; raltegravir (Isentress)2015<4020158Fixed Brain, Frozen Brain, Pituitary Gland, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, 37112015820158201520082016HIV+MaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
02383Criteria 1<40201648292368349384<5001000DRV; TMC-114, darunavir (Prezista), MVC; maraviroc (Selzentry), RGV; raltegravir (Isentress), RTV; ritonavir (Norvir)2017<4020168Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, 27, 28, 29, 30, 31, 33, 34920179201772017520179201720092017HIV+MaleWhiteNot HispanicDeceased with autopsy65+5-10 visits16 or more years
02398Criteria 2402012176066551043174017EFV; efavirenz (Sustiva), TRU; emtricitabine + tenofovir (Truvada)2012<4020123Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, 3732012220122201220092012HIV+MaleBlackHispanicDeceased with autopsy50-642-4 visits16 or more years
02422Criteria 2<4020121632332171401163<40163RGV; raltegravir (Isentress), TMC; TMC-125, etravirine (Intelence), TRU; emtricitabine + tenofovir (Truvada)2012<4020123Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, 27, 28, 29, 30, 31, 32, 34, 35, 38, 395201212012420123201220092013HIV+MaleMulti-racialHispanicDeceased with autopsy50-645-10 visits16 or more years
02479Criteria 1, Criteria 2<50201646774781554640007846DTG; dolutegravir (Tivicay), EPZ; ziagen + epivir (Epzicom)2016<5020166Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel1120151020159201511201520102016HIV+FemaleBlackHispanicDeceased with autopsy50-64>10 visits16 or more years
02480Criteria 1, Criteria 26582017101762792081065810DLV; delaviridine (Rescriptor), DSC; Emtricitabine (FTC) + Tenofovir Alafenamide (TAF) (Descovy)201765820177Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, 27, 28, 29, 30, 31, 32, 33, 34, 35, 38920178201742017620176201720102017HIV+MaleMulti-racialNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02500Criteria 1, Criteria 2<50201649359222643925139613COM; emtricitabine 200mg + rilpivirine 25mg + tenofovir DF 300mg (Complera)2016<5020166Fixed Brain, Frozen Brain, Spinal Cord, 27, 28, 29, 30, 31, 32, 33, 34, 354201242012220124201220102017HIV+FemaleWhiteNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02669Criteria 25020181237824098321287851543KTA; lopinavir/ritonavir (Kaletra), TRU; emtricitabine + tenofovir (Truvada)2015878520146Fixed Brain, Frozen Brain, Spinal Cord, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3812011120111201120112018HIV+MaleBlackNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02852Criteria 2<502016713429417271<5071DTG; dolutegravir (Tivicay), TRU; emtricitabine + tenofovir (Truvada)2016<5020163Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes5201642016520164201620132016HIV+MaleBlackNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02949Criteria 2202017127169459657212751638RGV; raltegravir (Isentress), TRU; emtricitabine + tenofovir (Truvada)20172020163Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, 27, 28, 29, 30, 31, 33, 342201712014320173201720142017HIV+MaleWhiteNot HispanicDeceased with autopsy50-642-4 visits16 or more years
03038Criteria 2<40201725100446962825<4025GEN; emtricitabine + tenofovir alafenamide (TAF) + elvitegravir + cobicistat (Genvoya)2017<4020172Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Kidney, Lung, Bowel, 3832017320173201720152017HIV+MaleWhiteHispanicDeceased with autopsy65+2-4 visits11-15 years
03054Criteria 220220171362504294429136337835DRV; TMC-114, darunavir (Prezista), RTV; ritonavir (Norvir), TRU; emtricitabine + tenofovir (Truvada)201720220172Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, 27, 28, 29, 30, 31, 32, 33, 34, 35, 384201742017120154201720152017HIV+MaleWhiteNot HispanicDeceased with autopsy65+2-4 visits16 or more years
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