Virally Suppressed Cases

A Unique resource available for HIV eradication research

Research toward a cure for HIV is one of the high priority topics of the NIH (NOT-OD-15-137). To effect a cure, reservoirs in which HIV persists despite treatment need to be identified and studied. However obtaining tissue for this work is challenging and for many organs is not possible. The National NeuroAIDS Tissue Consortium (NNTC, supported by NIMH and NINDS) represents a unique resource for such tissue. Subjects are studied longitudinally and donate biofluids (blood and cerebrospinal fluid) and agree to tissue donation upon death. While a distinct focus of the NNTC is the nervous system (and the brain is one potential reservoir), in addition to the brain and peripheral nervous system tissue other organs are collected at autopsy, including lymph nodes, heart, lung, liver, testes and more.

Of the over 900 autopsies in the NNTC tissue bank, we have identified 78 cases of subjects on antiretroviral treatment with viral suppression that show exceptional utility for HIV eradication research. We have reserved tissue and biofluids from these cases for allocation to investigators performing well-justified eradication research. Detailed information about these cases can be found below and forms for requesting tissue or fluids can be found here (nntc.org/content/requests).

The NNTC steering committee developed two different criteria to identify these cases, depending on the length of known suppression, and allowing for differences in the number and timing of viral load determinations before death in subjects on study.

Criteria 1. The subjects have been followed for at least 5 years before death. There must be at least 1 undetectable viral load within 1 year of death, or 2 undetectable viral loads within 2 years of death. Over the 5 year period before death, there must be at least 4 undetectable viral loads. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 5 year period.

Criteria 2. The subjects have been followed for at least 2 years before death. There must be at least 1 undetectable viral load within 6 months of death. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 2 year period.

33 cases met the first set of criteria, and 58 met the second. Of these, 22 cases met both sets of criteria. Investigators are of course welcome to examine the data and develop their own criteria, as well as ask us for assistance in identifying cases meeting their criteria. Furthermore, using our search tool (nntc.org/query/tool) tissue from our many other HIV+ subjects, as well as from HIV- controls can be requested.

Additional summary information is presented in the SUPPRESSION COHORT REPORTS PowerPoint presentation.

Click to view data fields presented on this cohort

Suppression Criteria (Criteria defined by the NNTC to classify deceased participants as virally suppressed. Currently we have used two criteria and the details are noted above in the cohort description.)
Last viral load
Last viral load measure year
Days between last viral load and death
Nadir CD4 count
Days between nadir CD4 and death
Last CD4 count
Days between CD4 measure and death
Highest viral load measure
Days between highest viral load and death
ARVs reported as current (Current ARV medication regimen at last assessment)
Last ARV report year (Year of last ARV medication assessment)
Viral load at last ARV report
Year of viral load at last ARV report
Length of time on study (Years)
Available autopsy specimens
Plasma Collections Available (# of unique collections of plasma where a sample is reported to be available)
Last plasma collection year (Year of last collection of plasma where a sample is reported to be available)
PBMCS collections available (# of unique collections of PBMCs where a sample is reported to be available)
Last PBMC collection year (Year of last collection of PBMCs where a sample is reported to be available)
CSF collections available (# of unique collections of CSF where a sample is reported to be available)
Last CSF collection year (Year of last collection of CSF where a sample is reported to be available)
Urine collections available (# of unique collections of urine where a sample is reported to be available)
Last urine collection year (Year of last collection of urine where a sample is reported to be available)
Serum collections available (# of unique collections of serum where a sample is reported to be available)
Last serum collection year (Year of last collection of serum where a sample is reported to be available)
Start year (Participant's enrollment date into the NNTC cohort)
Deceased year (Participant's year of death)
Endo/Exo-Chemical data (Availability of endo/exo-chemical data from previous research on case)
Morphometric data (Availability of morphometric data from previous research on case)
Gene Expression data (Availability of genotype data from previous research on case)
Genotype data (Availability of genotype data from previous research on case)
Protein data (Availability of protein data from previous research on case)
HIV Status
Gender
Other study data (Availability of other data from previous research on case)
Race
Ethnicity
Current status (Participant's current status in the study)
Age Interval at Last Visit (If active, age is based on last clinical visit or relative to today if no visit information is available. If inactive, age is based on date of inactive status. If deceased, age is based on date of death.)
# of clinic visits on study
Years with HIV

Horizontal Tabs

Virally Suppressed Cases

There are a total of 69 cases that meet all criteria

This reflects 2.1% of the total cohort of 3,257 cases

Case ID	Suppression Criteria	Last viral load	Last viral load measure year	Days between last viral load and death	Nadir CD4 count	Days between nadir CD4 and death	Last CD4 count	Days between CD4 measure and death	Highest viral load measure	Days between highest viral load and death	ARVs reported as current	Last ARV report year	Viral load at last ARV report	Year of viral load at last ARV report	Length of time on study	Available autopsy specimens	Plasma Collections Available	Last plasma collection year	PBMCS collections available	Last PBMC collection year	CSF collections available	Last CSF collection year	Urine collections available	Last urine collection year	Serum collections available	Last serum collection year	Start year	Deceased year	Endo/Exo-Chemical data	Morphometric data	Gene Expression data	Genotype data	Protein data	HIV Status	Gender	Other study data	Race	Ethnicity	Current status	Age Interval at Last Visit	# of clinic visits on study	Years with HIV
00006	Criteria 1, Criteria 2	<50	2009	99	205	484	392	99	671	1177	3TC, ABC, KTA	2009	<50	2009	5	Fixed Brain, Frozen Brain, Spinal Cord	10	2009	10	2009	4	2006	4	2008	7	2009	2003	2009		Yes	Yes	Yes	Yes	HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
00009	Criteria 2	<50	2010	113	188	2036	791	113	140241	2744	ATV, RTV, TRU	2010	<50	2010	6	Fixed Brain, Frozen Brain, Spinal Cord	13	2010	13	2010	2	2004	12	2010	11	2010	2003	2010		Yes	Yes	Yes	Yes	HIV+	Female	Yes	White	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00068	Criteria 1, Criteria 2	<400	2006	19	90	.	239	19	<400	19	3TC, ABC, NVP	2006	<400	2006	6	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel	5	2006	1	2006	3	2003			4	2006	1999	2006	Yes			Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
00152	Criteria 1	130	2019	234	75	.	433	58	35646	4550	DSC, DTG	2019	130	2019	17	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Peripheral Nerve, Lymph Node, Liver, Spleen, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum	15	2017	5	2017	6	2005			8	2013	2002	2020				Yes	Yes	HIV+	Female		Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00155	Criteria 2	140	2012	51	21	.	243	51	8663	3517	ATR	2010	<40	2010	9	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum	3	2010			1	2002			1	2002	2002	2012				Yes		HIV+	Male	Yes	White	Hispanic	Deceased with autopsy	35-49	2-4 visits	11-15 years
00256	Criteria 1, Criteria 2	20	2018	120	2	.	197	120	>750000	5985	RTV, TRU	2016	<40	2016	18	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum	7	2016	1	2012	3	2004			6	2016	2001	2019						HIV+	Male	Yes	Native Alaskan	Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
00522	Criteria 1	<50	2008	360	207	1900	465	458	<500	2547	ABC, EFV, KTA	2008	<50	2008	8	Fixed Brain, Frozen Brain, Pituitary Gland, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel	13	2008	12	2008	12	2008	12	2008	13	2008	2000	2009			Yes	Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	1 visit	16 or more years
00574	Criteria 1, Criteria 2	<50	2014	20	7	5802		20	>750000	6298	EPZ, FPV, RTV	2014	<50	2014	15	Fixed Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	33	2014	32	2014	9	2014	32	2014	25	2014	1999	2014	Yes			Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	65+	>10 visits	16 or more years
00590	Criteria 2	<50	2002	77	721	77	721	77	<50	77	3TC, NVP	2002	<50	2002	3	Fixed Brain	5	2002	5	2002	5	2002	5	2002			1999	2002		Yes		Yes	Yes	HIV+	Male		White	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	6-10 years
00599	Criteria 1, Criteria 2	<50	2015	55	65	2022	274	55	1033	6026	3TC	2015	<50	2015	16	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Testes	36	2015	33	2015	4	2015	31	2013	24	2015	1999	2015				Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00616	Criteria 2	<50	2006	146	125	2005	537	146	28701	1774	CBV	2006	<50	2006	7	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung	12	2006	10	2006			10	2006	3	2006	1999	2007	Yes	Yes	Yes	Yes	Yes	HIV+	Female	Yes	White	Hispanic	Deceased with autopsy	50-64	>10 visits	11-15 years
00630	Criteria 1, Criteria 2	<50	2006	157	182	609	271	20	<50	157	CBV, NFV	2006	<50	2006	6	Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	11	2006	11	2006	10	2006	11	2005	2	2006	2000	2006	Yes	Yes	Yes	Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	11-15 years
00632	Criteria 2	65	2005	34	66	164	136	34	21157	1980	ABC, d4T, TFV	2005	<50	2005	5	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	10	2005	7	2005	6	2005	8	2004	2	2005	2000	2005	Yes	Yes	Yes	Yes	Yes	HIV+	Male	Yes	White	Hispanic	Deceased with autopsy	50-64	5-10 visits	11-15 years
00641	Criteria 1, Criteria 2	<50	2014	27	6	2592	133	30	>750000	2660	ATV, RTV, TRU	2014	<50	2014	14	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	21	2013	19	2013	5	2007	7	2007	16	2013	2000	2014	Yes			Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00658	Criteria 1, Criteria 2	<50	2007	74	78	2	78	2	570975	2382	ATR	2007	<50	2007	7	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	11	2007	10	2007	4	2004	8	2006	5	2007	2000	2008	Yes	Yes	Yes	Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00691	Criteria 2	<50	2009	76	384	2824	1047	76	53136	1337	3TC, EFV, TFV	2009	<50	2009	6	Fixed Brain, Frozen Brain, Spinal Cord	11	2009	9	2008	1	2003	1	2003	6	2009	2002	2009			Yes	Yes	Yes	HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	35-49	>10 visits	11-15 years
00697	Criteria 2	<50	2004	130	318	856	798	130	327	1131	3TC, ABC, EFV	2004	<50	2004	2	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	3	2004	2	2004			1	2003			2003	2005	Yes	Yes		Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	2-4 visits	6-10 years
00699	Criteria 1, Criteria 2	<50	2010	180	312	1131	491	187	595	2608	3TC, ABC, EFV	2010	<50	2010	8	Fixed Brain, Frozen Brain, Spinal Cord	17	2010	15	2010			12	2010	12	2010	2003	2011		Yes		Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00703	Criteria 1, Criteria 2	<50	2013	103	54	3883	140	103	3833	3883	3TC, EFV, TFV	2013	<50	2013	10	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes	25	2013	21	2013	5	2005	17	2012	21	2013	2003	2014				Yes		HIV+	Male	Yes	Multi-racial	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00704	Criteria 1, Criteria 2	<50	2009	149	128	149	128	149	96	3070	CBV	2009	<50	2009	6	Fixed Brain, Frozen Brain, Spinal Cord	11	2009	9	2009			7	2009	8	2009	2003	2009				Yes	Yes	HIV+	Female	Yes	Black	Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
00719	Criteria 2	<50	2001	52	8	808	219	57	245900	808	3TC, d4T, NFV	2001	<50	2001	2	Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Testes	4	2001	4	2001	4	2001	1	1999			1999	2001	Yes	Yes	Yes	Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	35-49	5-10 visits	6-10 years
00739	Criteria 2	<50	2003	92	230	866	383	126	<50	92	3TC, d4T, EFV	2003	<50	2003	3	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	7	2003	1	2003			4	2002			2000	2003	Yes	Yes			Yes	HIV+	Male		White	Hispanic	Deceased with autopsy	50-64	5-10 visits	11-15 years
00865	Criteria 1, Criteria 2	0	2005	177	13	3695	785	177	26668	1986	NONE	2006	0	2005	5	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	11	2005	8	2004	10	2005			10	2005	2000	2006	Yes			Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	35-49	No ante-mortem visit	16 or more years
00927	Criteria 2	14	2007	157	3	3875	67	157	57300	853	NONE	2008	14	2007	5	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	9	2007			5	2007			8	2007	2002	2007	Yes			Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	35-49	No ante-mortem visit	6-10 years
00946	Criteria 2	0	2014	48	29	4396	430	48	49	4249	DRV, RTV, TRU	2014	0	2014	11	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	14	2014	3	2012	10	2014			13	2014	2002	2014				Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	2-4 visits	11-15 years
00965	Criteria 2	0	2006	113	75	.	381	113	11	1357	NONE	2006	0	2006	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	7	2006	1	2004	6	2006			7	2006	2003	2006	Yes		Yes	Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	No ante-mortem visit	11-15 years
01117	Criteria 2	0	2004	87	8	2676	309	87	0	87	3TC, EFV, FPV, RTV, ZDV	2004	0	2004	4	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	4	2004			4	2004			5	2004	2000	2005	Yes		Yes	Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	No ante-mortem visit	16 or more years
01132	Criteria 2	75	2007	108	8	.	1275	108	3169	1004	FTC, KTA, RTV, TFV	2007	75	2007	6	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Urine	11	2007	6	2007					8	2007	2001	2007				Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	No ante-mortem visit	16 or more years
01305	Criteria 2	143	2005	180	114	2473	246	180	1003	1145	ABC, FPV, FTC, NVP, RTV, TFV	2005	143	2005	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	6	2005			2	2003			4	2005	2003	2006	Yes			Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	35-49	No ante-mortem visit	16 or more years
01374	Criteria 2	85	2011	48	2	.	491	218	<400	2639	NONE		.		12	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel	6	2011	2	2011	3	2004			3	2004	1999	2012				Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
01396	Criteria 1, Criteria 2	40	2010	81	7	.	69	81	795	3647	3TC, RTV, SQV, TFV	2010	40	2010	10	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel	12	2010	4	2009	2	2004			12	2010	2000	2011		Yes	Yes	Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
01410	Criteria 2	<50	2009	132	142	887	267	132	35096	2413	3TC, ABC, FPV, RTV	2009	<50	2009	6	Fixed Brain, Frozen Brain, Spinal Cord	14	2009	13	2009	4	2008	6	2007	10	2009	2003	2010	Yes	Yes		Yes	Yes	HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
01495	Criteria 2	40	2009	0	17	.	112	67	185983	2058	DRV, RTV, TRU	2009	<40	2009	5	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum, Post-mortem Fluid	3	2009							3	2009	2004	2009				Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	35-49	5-10 visits	11-15 years
01565	Criteria 2	<400	2006	93	151	940	213	93	<400	93	NONE		.		2	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Lymph Node, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum	2	2006							2	2005	2004	2006	Yes	Yes	Yes	Yes	Yes	HIV+	Male		White	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	11-15 years
01731	Criteria 2	<50	2009	163	217	2123	680	172	169913	1292	3TC, ATV, RTV, TFV	2009	<50	2009	4	Fixed Brain, Frozen Brain, Spinal Cord	6	2009	6	2009					4	2009	2005	2009						HIV+	Female	Yes	Black	Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
01806	Criteria 1	88	2010	329	66	500	66	500	<400	1547	d4T, DRV, RGV, RTV, TRU	2010	88	2010	5	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung	7	2010					7	2010	7	2010	2005	2011			Yes	Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
01866	Criteria 2	139	2008	46	64	1669	117	21	29324	1414	3TC, ATV, RTV, TFV	2008	53	2008	3	Fixed Brain, Frozen Brain, Spinal Cord	7	2008	7	2008	1	2005	5	2008	5	2008	2005	2009		Yes		Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
01878	Criteria 1	<50	2011	200	99	549	133	200	50	200	NVP, TRU	2011	<50	2011	6	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	9	2011	8	2011	4	2007	8	2010	7	2011	2005	2012				Yes	Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
01986	Criteria 1, Criteria 2	20	2015	30	30	.	355	30	3222	2911	ATV, EPZ	2013	<40	2013	9	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Thymus, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum	9	2013	9	2013	3	2008			7	2013	2006	2015						HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	5-10 visits	16 or more years
01987	Criteria 1, Criteria 2	20	2020	33	107	.	888	33	<400	917	TMQ	2020	20	2020	13	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	6	2017	5	2017	2	2009			6	2017	2006	2020						HIV+	Male	Yes	Native Alaskan	Hispanic	Deceased with autopsy	65+	5-10 visits	16 or more years
02035	Criteria 1, Criteria 2	20	2015	138	25	3030	300	138	3974	2328	ATV, RTV, TRU	2014	20	2014	9	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel	10	2014	10	2015	1	2015	10	2014	10	2014	2006	2015						HIV+	Male		Unknown	Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
02041	Criteria 2	50	2019	7	0	.	141	8	256664	3549	NONE	2019	50	2019	12	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	18	2017	17	2013	2	2010	13	2013	17	2017	2006	2019				Yes		HIV+	Female	Yes	White	Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02087	Criteria 1	<50	2011	552	184	752	223	552	124	752	RGV, TMC, TRU	2012	<50	2011	6	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes	8	2011	8	2011	1	2006	8	2011	8	2011	2006	2012				Yes		HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
02104	Criteria 2	48	2010	14	61	.	61	14	302830	1941	DRV, RTV, TRU	2009	<40	2009	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum	2	2009	1	2006					1	2009	2006	2010			Yes	Yes	Yes	HIV+	Male	Yes	White	Hispanic	Deceased with autopsy	35-49	2-4 visits	16 or more years
02122	Criteria 2	<50	2009	134	360	918	518	506	13852	1106	KTA, TRU	2009	<50	2009	2	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Muscle, Heart, Kidney, Lung	1	2007			1	2009	1	2009			2007	2009			Yes	Yes		HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
02161	Criteria 1	20	2016	274	317	5046	681	12	618	2709	DTG, TRU	2016	20	2016	10	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia	11	2016	10	2015	1	2017	9	2016	11	2016	2007	2017						HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	65+	5-10 visits	16 or more years
02206	Criteria 2	<50	2017	75	325	.	747	75	69414	2280	ATV, DTG, RTV, TRU	2017	<50	2017	9	Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	11	2017	12	2017	1	2007	8	2017	11	2017	2007	2017				Yes		HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02217	Criteria 1	<50	2019	246	140	.	170	3	230370	2962	DSC, RGV	2020	<50	2019	12	Fixed Brain, Frozen Brain, Lymph Node, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	15	2019	15	2019			15	2019	15	2019	2007	2020				Yes		HIV+	Female	Yes	Multi-racial	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02222	Criteria 1, Criteria 2	<50	2020	171	138	2943	685	164	250000	6810	EFV, RGV	2020	<50	2020	13	Fixed Brain, Frozen Brain, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	15	2020	16	2020	4	2019	10	2019	14	2020	2007	2021				Yes		HIV+	Female	Yes	Black	Not Hispanic	Active	50-64	>10 visits	16 or more years
02225	Criteria 2	40	2010	0	161	.	161	9	83135	962	RGV, TRU	2010	<40	2010	3	Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum	4	2010	1	2007					2	2010	2007	2010				Yes	Yes	HIV+	Female	Yes	White	Hispanic	Deceased with autopsy	50-64	2-4 visits	6-10 years
02235	Criteria 2	<50	2014	162	324	.	493	162	10388	1296	DRV, EPZ, RGV, RTV	2014	<50	2014	7	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung	11	2014	11	2014					11	2014	2007	2015				Yes		HIV+	Female	Yes	White	Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02252	Criteria 2	<50	2010	133	81	2278	425	133	39000	2278	ATR	2010	<50	2010	2	Fixed Brain, Frozen Brain, Spinal Cord	3	2010	3	2010			3	2010	3	2010	2007	2010		Yes		Yes	Yes	HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	35-49	2-4 visits	11-15 years
02300	Criteria 1	<40	2015	192	36	2127	294	192	>100000	3082	NONE	2015	<40	2015	8	Fixed Brain, Frozen Brain, Pituitary Gland, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Post-mortem CSF	11	2015	6	2013					7	2015	2008	2016						HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02383	Criteria 1	<40	2016	384	9	2368	349	384	<500	1000	DRV, MVC, RGV, RTV	2017	<40	2016	8	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia	9	2017	9	2017	8	2017	5	2017	9	2017	2009	2017					Yes	HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	5-10 visits	16 or more years
02398	Criteria 2	40	2012	17	60	.	1043	17	40	17	EFV, TRU	2012	<40	2012	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF	3	2012	2	2012					1	2012	2009	2012				Yes	Yes	HIV+	Male	Yes	Black	Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
02422	Criteria 2	40	2012	163	233	.	401	163	40	163	RGV, TMC, TRU	2012	40	2012	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum, Post-mortem Urine	5	2012			4	2012			3	2012	2009	2013						HIV+	Male		Multi-racial	Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
02479	Criteria 1, Criteria 2	<50	2016	46	77	478	155	46	4000	7846	DTG, EPZ	2016	<50	2016	6	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel	11	2015	10	2015			9	2015	11	2015	2010	2016				Yes		HIV+	Female	Yes	Black	Hispanic	Deceased with autopsy	50-64	>10 visits	16 or more years
02480	Criteria 1, Criteria 2	658	2017	10	17	.	208	10	658	10	NONE	2017	658	2017	7	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	9	2017	8	2017	4	2017	6	2017	6	2017	2010	2017				Yes		HIV+	Male	Yes	Multi-racial	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
02500	Criteria 1, Criteria 2	<50	2016	49	359	2226	439	25	139	613	NONE	2016	<50	2016	6	Fixed Brain, Frozen Brain, Spinal Cord, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	4	2012	4	2012			2	2012	4	2012	2010	2017				Yes		HIV+	Female		White	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
02657	Criteria 1, Criteria 2	<50	2020	120	0	.	298	13	739	2570	TMQ	2020	<50	2020	9	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	21	2020	17	2020	5	2019	14	2020	17	2020	2011	2021						HIV+	Male	Yes	Black	Hispanic	Active	65+	>10 visits	16 or more years
02669	Criteria 2	50	2018	12	378	2409	832	12	8785	1543	KTA, RGV	2018	50	2018	6	Fixed Brain, Frozen Brain, Spinal Cord, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	1	2011	1	2011					1	2011	2011	2018						HIV+	Male		Black	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
02696	Criteria 1, Criteria 2	<50	2019	123	2	.	598	124	106	830	3TC, ABC, DTG	2018	<50	2018	7	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	12	2018	11	2018			10	2017	12	2018	2011	2019						HIV+	Female	Yes	Black	Not Hispanic	Deceased with autopsy	65+	>10 visits	16 or more years
02728	Criteria 1	<50	2019	311	42	12	1140	311	543	3320	QUA	2019	<50	2019	8	Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	18	2020	17	2020	6	2019	8	2019	15	2018	2012	2020					Yes	HIV+	Male	Yes	White	Hispanic	Active	65+	>10 visits	16 or more years
02837	Criteria 1	<50	2020	413	30	.	559	172	671	4237	TMQ	2020	<50	2020	7	Fixed Brain, Frozen Brain, Spinal Cord, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	10	2020	11	2020			11	2020	11	2020	2013	2021						HIV+	Male	Yes	Black	Not Hispanic	Active	65+	>10 visits	16 or more years
02852	Criteria 2	<50	2016	71	34	295	172	71	<50	71	DTG, TRU	2016	<50	2016	3	Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes	5	2016	4	2016			5	2016	4	2016	2013	2016				Yes	Yes	HIV+	Male	Yes	Black	Not Hispanic	Deceased with autopsy	50-64	5-10 visits	16 or more years
02949	Criteria 2	<40	2017	127	169	4596	572	127	218	1115	RGV, TRU	2017	20	2016	3	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia	2	2017	1	2014	1	2017	3	2017	3	2017	2014	2017						HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	50-64	2-4 visits	16 or more years
03038	Criteria 2	<40	2017	25	100	.	628	25	<40	25	NONE	2017	<40	2017	2	Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum	3	2017	3	2017					2	2017	2015	2017						HIV+	Male		White	Hispanic	Deceased with autopsy	65+	2-4 visits	11-15 years
03054	Criteria 2	202	2017	136	250	4294	429	136	337	835	DRV, RTV, TRU	2017	202	2017	2	Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum	4	2017	4	2017	1	2015			4	2017	2015	2017				Yes		HIV+	Male	Yes	White	Not Hispanic	Deceased with autopsy	65+	2-4 visits	16 or more years
05185	Criteria 2	<50	2019	79	3	.	641	79	76575	6399	NONE	2019	<50	2019	3	Fixed Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma	3	2019	3	2019			3	2019	3	2019	2016	2020						HIV+	Male		Multi-racial	Hispanic	Deceased with autopsy	65+	2-4 visits	16 or more years

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