Virally Suppressed Cases

A Unique resource available for HIV eradication research

Research toward a cure for HIV is one of the high priority topics of the NIH (NOT-OD-15-137). To effect a cure, reservoirs in which HIV persists despite treatment need to be identified and studied. However obtaining tissue for this work is challenging and for many organs is not possible. The National NeuroAIDS Tissue Consortium (NNTC, supported by NIMH and NINDS) represents a unique resource for such tissue. Subjects are studied longitudinally and donate biofluids (blood and cerebrospinal fluid) and agree to tissue donation upon death. While a distinct focus of the NNTC is the nervous system (and the brain is one potential reservoir), in addition to the brain and peripheral nervous system tissue other organs are collected at autopsy, including lymph nodes, heart, lung, liver, testes and more.

Of the over 900 autopsies in the NNTC tissue bank, we have identified 66 cases of subjects on antiretroviral treatment with viral suppression that show exceptional utility for HIV eradication research. We have reserved tissue and biofluids from these cases for allocation to investigators performing well-justified eradication research. Detailed information about these cases can be found below and forms for requesting tissue or fluids can be found here (nntc.org/content/requests).

The NNTC steering committee developed two different criteria to identify these cases, depending on the length of known suppression, and allowing for differences in the number and timing of viral load determinations before death in subjects on study.

Criteria 1. The subjects have been followed for at least 5 years before death. There must be at least 1 undetectable viral load within 1 year of death, or 2 undetectable viral loads within 2 years of death. Over the 5 year period before death, there must be at least 4 undetectable viral loads. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 5 year period.

Criteria 2. The subjects have been followed for at least 2 years before death.  There must be at least 1 undetectable viral load within 6 months of death. Note that “blips” of detectable virus are allowed, however these must be <1000 copies/mL during this 2 year period.

30 cases met the first set of criteria, and 57 met the second. Of these, 21 cases met both sets of criteria. Investigators are of course welcome to examine the data and develop their own criteria, as well as ask us for assistance in identifying cases meeting their criteria. Furthermore, using our search tool (nntc.org/query/tool) tissue from our many other HIV+ subjects, as well as from HIV- controls can be requested.

Additional summary information is presented in the SUPPRESSION COHORT REPORTS PowerPoint presentation.

There are a total of 70 cases that meet all criteria
This reflects 2.1% of the total cohort of 3,295 cases
Case IDSuppression CriteriaCriteria defined by the NNTC to classify deceased participants as virally suppressed. Currently we have used two criteria and the details are noted above in the cohort description.Last viral loadLast viral load measure yearDays between last viral load and deathNadir CD4 countDays between nadir CD4 and deathLast CD4 countDays between CD4 measure and deathHighest viral load measureDays between highest viral load and deathARVs reported as currentCurrent ARV medication regimen at last assessmentLast ARV report yearYear of last ARV medication assessmentViral load at last ARV reportYear of viral load at last ARV reportLength of time on studyYearsAvailable autopsy specimensPlasma Collections Available# of unique collections of plasma where a sample is reported to be availableLast plasma collection yearYear of last collection of plasma where a sample is reported to be availablePBMCS collections available# of unique collections of PBMCs where a sample is reported to be availableLast PBMC collection yearYear of last collection of PBMCs where a sample is reported to be availableCSF collections available# of unique collections of CSF where a sample is reported to be availableLast CSF collection yearYear of last collection of CSF where a sample is reported to be availableUrine collections available# of unique collections of urine where a sample is reported to be availableLast urine collection yearYear of last collection of urine where a sample is reported to be availableSerum collections available# of unique collections of serum where a sample is reported to be availableLast serum collection yearYear of last collection of serum where a sample is reported to be availableStart yearParticipant's enrollment date into the NNTC cohortDeceased yearParticipant's year of deathEndo/Exo-Chemical dataAvailability of endo/exo-chemical data from previous research on caseMorphometric dataAvailability of morphometric data from previous research on caseGene Expression dataAvailability of genotype data from previous research on caseGenotype dataAvailability of genotype data from previous research on caseProtein dataAvailability of protein data from previous research on caseHIV StatusGenderRaceOther study dataAvailability of other data from previous research on caseEthnicityCurrent statusParticipant's current status in the studyAge Interval at Last VisitIf active, age is based on last clinical visit or relative to today if no visit information is available. If inactive, age is based on date of inactive status. If deceased, age is based on date of death.# of clinic visits on studyYears with HIV
00006Criteria 1, Criteria 2<502009992054843929967111773TC, ABC, KTA2009<5020095Fixed Brain, Frozen Brain, Spinal Cord10200910200942006420087200920032009YesYesYesYesHIV+FemaleBlackYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
00009Criteria 2<50201011318820367911131402412744ATV, RTV, TRU2010<5020106Fixed Brain, Frozen Brain, Spinal Cord1320101320102200412201011201020032010YesYesYesYesHIV+FemaleWhiteYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00068Criteria 1, Criteria 2<40020061990.23919<400193TC, ABC, NVP2006<40020066Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel5200612006320034200619992006YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
00136Criteria 202016710.3037126390547063TC, DRV, RGV, RTV2015<40201515Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum8201532015520076201520012016YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+5-10 visits16 or more years
00152Criteria 1, Criteria 23020201475.43358356464550DSC, DTG2019130201917Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Peripheral Nerve, Lymph Node, Liver, Spleen, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum15201752017620058201320022020YesYesHIV+FemaleBlackNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00155Criteria 214020125121.2435186633517ATR2010<4020109Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum32010120021200220022012YesHIV+MaleWhiteYesHispanicDeceased with autopsy35-492-4 visits11-15 years
00256Criteria 1, Criteria 22020181202.197120>7500005985RTV, TRU2016<40201618Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum7201612012320046201620012019HIV+MaleNative AlaskanYesHispanicDeceased with autopsy50-645-10 visits16 or more years
00522Criteria 1<5020083602071900465458<5002547ABC, EFV, KTA2008<5020088Fixed Brain, Frozen Brain, Pituitary Gland, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel13200812200812200812200813200820002009YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+1 visit16 or more years
00574Criteria 1, Criteria 2<502014207580220>7500006298EPZ, FPV, RTV2014<50201415Fixed Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes3320143220149201432201425201419992014YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy65+>10 visits16 or more years
00590Criteria 2<502002777217772177<50773TC, NVP2002<5020023Fixed Brain5200252002520025200219992002YesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-645-10 visits6-10 years
00599Criteria 1, Criteria 2<5020155565202227455103360263TC2015<50201516Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Testes3620153320154201531201324201519992015YesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00616Criteria 2<5020061461252005537146287011774CBV2006<5020067Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung1220061020061020063200619992007YesYesYesYesYesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-64>10 visits11-15 years
00630Criteria 1, Criteria 2<50200615718260927120<50157CBV, NFV2006<5020066Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes1120061120061020061120052200620002006YesYesYesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits11-15 years
00632Criteria 2652005346616413634211571980ABC, d4T, TFV2005<5020055Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes1020057200562005820042200520002005YesYesYesYesYesHIV+MaleWhiteYesHispanicDeceased with autopsy50-645-10 visits11-15 years
00641Criteria 1, Criteria 2<502014276259213330>7500002660ATV, RTV, TRU2014<50201414Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes212013192013520077200716201320002014YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00658Criteria 1, Criteria 2<502007747827825709752382ATR2007<5020077Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes11200710200742004820065200720002008YesYesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00691Criteria 2<5020097638428241047765313613373TC, EFV, TFV2009<5020096Fixed Brain, Frozen Brain, Spinal Cord1120099200812003120036200920022009YesYesYesHIV+FemaleBlackYesNot HispanicDeceased with autopsy35-49>10 visits11-15 years
00697Criteria 2<50200413031885679813032711313TC, ABC, EFV2004<5020042Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes32004220041200320032005YesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+2-4 visits6-10 years
00699Criteria 1, Criteria 2<502010180312113149118759526083TC, ABC, EFV2010<5020108Fixed Brain, Frozen Brain, Spinal Cord17201015201012201012201020032011YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00703Criteria 1, Criteria 2<502013103543883140103383338833TC, EFV, TFV2013<50201310Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes2520132120135200517201221201320032014YesHIV+MaleMulti-racialYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
00704Criteria 1, Criteria 2<502009149128149128149963070CBV2009<5020096Fixed Brain, Frozen Brain, Spinal Cord11200992009720098200920032009YesYesHIV+FemaleBlackYesHispanicDeceased with autopsy50-64>10 visits16 or more years
00719Criteria 2<502001528808219572459008083TC, d4T, NFV2001<5020012Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Testes4200142001420011199919992001YesYesYesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy35-495-10 visits6-10 years
00739Criteria 2<50200392230866383126<50923TC, d4T, EFV2003<5020033Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes72003120034200220002003YesYesYesHIV+MaleWhiteHispanicDeceased with autopsy50-645-10 visits11-15 years
00865Criteria 1, Criteria 202005177133695785177266681986NONE2006020055Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma1120058200410200510200520002006YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy35-49No ante-mortem visit16 or more years
00927Criteria 2142007157338756715757300853NONE20081420075Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma92007520078200720022007YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy35-49No ante-mortem visit6-10 years
00946Criteria 2020144829439643048494249DRV, RTV, TRU20140201411Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum1420143201210201413201420022014YesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+2-4 visits11-15 years
00965Criteria 20200611375.381113111357NONE2006020063Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma7200612004620067200620032006YesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64No ante-mortem visit11-15 years
01117Criteria 2020048782676309870873TC, EFV, FPV, RTV, ZDV2004020044Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma42004420045200420002005YesYesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-64No ante-mortem visit16 or more years
01132Criteria 27520071088.127510831691004FTC, KTA, RTV, TFV20077520076Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Urine112007620078200720012007YesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64No ante-mortem visit16 or more years
01305Criteria 21432005180114247324618010031145ABC, FPV, FTC, NVP, RTV, TFV200514320053Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Hair, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum62005220034200520032006YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy35-49No ante-mortem visit16 or more years
01374Criteria 2852011482.491218<4002639NONE.12Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel6201122011320043200419992012YesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01396Criteria 1, Criteria 2402010817.698179536473TC, RTV, SQV, TFV201040201010Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel122010420092200412201020002011YesYesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
01410Criteria 2<5020091321428872671323509624133TC, ABC, FPV, RTV2009<5020096Fixed Brain, Frozen Brain, Spinal Cord142009132009420086200710200920032010YesYesYesYesHIV+FemaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
01495Criteria 2<4020096717.112671859832058DRV, RTV, TRU2009<4020095Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum, Post-mortem Fluid320093200920042009YesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy35-495-10 visits11-15 years
01565Criteria 2<40020069315194021393<40093NONE.2Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Lymph Node, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum220062200520042006YesYesYesYesYesHIV+MaleWhiteNot HispanicDeceased with autopsy50-642-4 visits11-15 years
01731Criteria 2<502009163217212368017216991312923TC, ATV, RTV, TFV2009<5020094Fixed Brain, Frozen Brain, Spinal Cord62009620094200920052009HIV+FemaleBlackYesHispanicDeceased with autopsy50-645-10 visits16 or more years
01806Criteria 18820103296650066500<4001547d4T, DRV, RGV, RTV, TRU20108820105Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Muscle, Heart, Kidney, Lung72010720107201020052011YesYesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-642-4 visits16 or more years
01866Criteria 2139200846641669117212932414143TC, ATV, RTV, TFV20085320083Fixed Brain, Frozen Brain, Spinal Cord720087200812005520085200820052009YesYesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01878Criteria 1<5020112009954913320050200NVP, TRU2011<5020116Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes920118201142007820107201120052012YesYesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
01986Criteria 1, Criteria 22020153030.3553032222911ATV, EPZ2013<4020139Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Liver, Adipose Tissue, Bone Marrow, Muscle, Heart, Thymus, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum9201392013320087201320062015HIV+MaleWhiteYesNot HispanicDeceased with autopsy65+5-10 visits16 or more years
01987Criteria 1, Criteria 220202033107.88833<4004673TMQ202020202013Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Liver, Spleen, Adipose Tissue, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum6201752017220096201720062020HIV+MaleNative AlaskanYesHispanicDeceased with autopsy65+5-10 visits16 or more years
02035Criteria 1, Criteria 220201513825303030013839742328ATV, RTV, TRU20142020149Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Liver, Spleen, Muscle, Heart, Kidney, Lung, Bowel1020141020151201510201410201420062015HIV+MaleUnknownHispanicDeceased with autopsy50-645-10 visits16 or more years
02041Criteria 250201970.14182566643549NONE201950201912Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum1820171720132201013201317201720062019YesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-64>10 visits16 or more years
02087Criteria 1<502011552184752223552124752RGV, TMC, TRU2012<5020116Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Testes820118201112006820118201120062012YesHIV+MaleWhiteYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02104Criteria 24820101461.61143028301941DRV, RTV, TRU2009<4020093Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum22009120061200920062010YesYesYesHIV+MaleWhiteYesHispanicDeceased with autopsy35-492-4 visits16 or more years
02122Criteria 2<502009134360918518506138521106KTA, TRU2009<5020092Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Muscle, Heart, Kidney, Lung12007120091200920072009YesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-642-4 visits16 or more years
02161Criteria 12020162743175046681126182709DTG, TRU201620201610Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia112016102015120179201611201620072017HIV+MaleBlackYesNot HispanicDeceased with autopsy65+5-10 visits16 or more years
02206Criteria 2<50201775325.74775694142280ATV, DTG, RTV, TRU2017<5020179Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum112017122017120078201711201720072017YesHIV+FemaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
02217Criteria 1<502019246140.4842462303702962DSC, RGV2020<50201912Fixed Brain, Frozen Brain15201915201915201915201920072020YesHIV+FemaleMulti-racialYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
02225Criteria 2<40201043161.161983135962RGV, TRU2010<4020103Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF, Post-mortem Serum42010120072201020072010YesYesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-642-4 visits6-10 years
02235Criteria 2<502014162324.493162103881296DRV, EPZ, RGV, RTV2014<5020147Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung11201411201411201420072015YesHIV+FemaleWhiteYesHispanicDeceased with autopsy50-64>10 visits16 or more years
02252Criteria 2<502010133812278425133390002278ATR2010<5020102Fixed Brain, Frozen Brain, Spinal Cord3201032010320103201020072010YesYesYesHIV+FemaleBlackYesNot HispanicDeceased with autopsy35-492-4 visits11-15 years
02300Criteria 1, Criteria 2020163362127294192>1000003082NONE2015<4020158Fixed Brain, Frozen Brain, Pituitary Gland, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Post-mortem CSF112015620137201520082016HIV+MaleBlackYesNot HispanicDeceased with autopsy50-64>10 visits16 or more years
02383Criteria 1<40201638492368349384<5001000DRV, MVC, RGV, RTV2017<4020168Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia920179201782017520179201720092017YesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+5-10 visits16 or more years
02398Criteria 24020121760.1043174017EFV, TRU2012<4020123Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Heart, Kidney, Lung, Bowel, Post-mortem CSF32012220121201220092012YesYesHIV+MaleBlackYesHispanicDeceased with autopsy50-642-4 visits16 or more years
02422Criteria 2402012163233.40116340163RGV, TMC, TRU20124020123Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum, Post-mortem Urine52012420123201220092013HIV+MaleMulti-racialHispanicDeceased with autopsy50-645-10 visits16 or more years
02479Criteria 1, Criteria 2<50201646774781554640007846DTG, EPZ2016<5020166Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel1120151020159201511201520102016YesHIV+FemaleBlackYesHispanicDeceased with autopsy50-64>10 visits16 or more years
02480Criteria 1, Criteria 265820171017.2081065810NONE201765820177Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum920178201742017620176201720102017YesHIV+MaleMulti-racialYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02500Criteria 1, Criteria 2<50201649359222643925139613NONE2016<5020166Fixed Brain, Frozen Brain, Spinal Cord, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma4201242012220124201220102017YesHIV+FemaleWhiteNot HispanicDeceased with autopsy50-642-4 visits16 or more years
02593Criteria 120201828829220155802881801924DRV, FTC, RGV, RTV, TFV20192020188Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum62016420164201520112019HIV+MaleBlackYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02657Criteria 1, Criteria 2<502020130.298137392570TMQ2020<5020209Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum2120201720205201914202017202020112021HIV+MaleBlackYesHispanicDeceased with autopsy65+>10 visits11-15 years
02669Criteria 25020181237824098321287851543KTA, RGV20185020186Fixed Brain, Frozen Brain, Spinal Cord, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum12011120111201120112018HIV+MaleBlackNot HispanicDeceased with autopsy50-642-4 visits16 or more years
02696Criteria 1, Criteria 2<5020191232.5981241068303TC, ABC, DTG2018<5020187Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum12201811201810201712201820112019HIV+FemaleBlackYesNot HispanicDeceased with autopsy65+>10 visits16 or more years
02728Criteria 1<502019311160.11403115433320QUA2019<5020198Fixed Brain, Frozen Brain, Spinal Cord182020172020620198201915201820122020YesHIV+MaleWhiteYesHispanicDeceased with autopsy65+>10 visits16 or more years
02852Criteria 2<502016713429517271<5071DTG, TRU2016<5020163Fixed Brain, Frozen Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes5201642016520164201620132016YesYesHIV+MaleBlackYesNot HispanicDeceased with autopsy50-645-10 visits16 or more years
02949Criteria 2<40201712716945965721272181115RGV, TRU20172020163Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Thalamus, Basal Ganglia220171201412017320173201720142017HIV+MaleWhiteYesNot HispanicDeceased with autopsy50-642-4 visits16 or more years
03035Criteria 1, Criteria 2020208012.215581860003303GEN20192020185Fixed Brain, Frozen Brain, Spinal Cord, Peripheral Nerve, Lymph Node, Liver, Bone Marrow, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma42018220181201620152020HIV+MaleWhiteNot HispanicDeceased with autopsy65+5-10 visits16 or more years
03038Criteria 2<40201725100.62825<4025NONE2017<4020172Fixed Brain, Frozen Brain, Spinal Cord, Pituitary Gland, Trigeminal Ganglia, Peripheral Nerve, Liver, Spleen, Adipose Tissue, Muscle, Heart, Kidney, Lung, Bowel, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem CSF, Post-mortem Serum32017320172201720152017HIV+MaleWhiteHispanicDeceased with autopsy65+2-4 visits11-15 years
03054Criteria 220220171362504294429136337835DRV, RTV, TRU201720220172Fixed Brain, Frozen Brain, Spinal Cord, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma, Post-mortem Serum4201742017120154201720152017YesHIV+MaleWhiteYesNot HispanicDeceased with autopsy65+2-4 visits16 or more years
05185Criteria 2<502019793.64179765756399NONE2019<5020193Fixed Brain, Spinal Cord, Trigeminal Ganglia, Dorsal Root Ganglia, Peripheral Nerve, Lymph Node, Liver, Spleen, Adipose Tissue, Bone Marrow, Muscle, Heart, Kidney, Lung, Bowel, Testes, Frontal Lobe, Parietal Lobe, Occipital Lobe, Temporal Lobe, Hippocampus, Brain Stem, Thalamus, Basal Ganglia, Post-mortem Plasma3201932019320193201920162020HIV+MaleMulti-racialHispanicDeceased with autopsy65+2-4 visits16 or more years
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