GluT4: A central player in hippocampal memory and brain insulin resistance.
Submitted by dcc on Tue, 10/13/2020 - 12:03pm
Title | GluT4: A central player in hippocampal memory and brain insulin resistance. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | McNay, EC, Pearson-Leary, J |
Journal | Exp Neurol |
Volume | 323 |
Pagination | 113076 |
Date Published | 2020 01 |
ISSN | 1090-2430 |
Keywords | Animals, CHARTER, Cognitive Dysfunction, Glucose Transporter Type 4, Hippocampus, Humans, Insulin Resistance, Internal, Memory, Short-Term |
Abstract | Insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. Impairments to insulin signaling, such as those seen in type 2 diabetes and Alzheimer's disease, are associated with brain hypometabolism and cognitive impairment, but the mechanisms of insulin's central effects are not determined. Several lines of research converge to suggest that the insulin-responsive glucose transporter GluT4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance. |
DOI | 10.1016/j.expneurol.2019.113076 |
Alternate Journal | Exp Neurol |
PubMed ID | 31614121 |
PubMed Central ID | PMC6936336 |
Grant List | R01 AG050598 / AG / NIA NIH HHS / United States R01 DK077106 / DK / NIDDK NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States HHSN271201000030C / MH / NIMH NIH HHS / United States |