The role of connexin and pannexin containing channels in the innate and acquired immune response.
Title | The role of connexin and pannexin containing channels in the innate and acquired immune response. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Valdebenito, S, Barreto, A, Eugenin, EA |
Journal | Biochim Biophys Acta Biomembr |
Volume | 1860 |
Issue | 1 |
Pagination | 154-165 |
Date Published | 01/2018 |
ISSN | 0005-2736 |
Keywords | Adaptive Immunity, Animals, Bacteria, Bacterial Infections, Connexins, gap junctions, HIV Infections, HIV-1, Humans, Immunity, Innate |
Abstract | Connexin (Cx) and pannexin (Panx) containing channels - gap junctions (GJs) and hemichannels (HCs) - are present in virtually all cells and tissues. Currently, the role of these channels under physiological conditions is well defined. However, their role in the immune response and pathological conditions has only recently been explored. Data from several laboratories demonstrates that infectious agents, including HIV, have evolved to take advantage of GJs and HCs to improve viral/bacterial replication, enhance inflammation, and help spread toxicity into neighboring areas. In the current review, we discuss the role of Cx and Panx containing channels in immune activation and the pathogenesis of several infectious diseases. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve. |
DOI | 10.1016/j.bbamem.2017.05.015 |
Alternate Journal | Biochim Biophys Acta Biomembr |
PubMed ID | 28559189 |
PubMed Central ID | PMC6065251 |
Grant List | R01 MH096625 / MH / NIMH NIH HHS / United States R01 NS105584 / NS / NINDS NIH HHS / United States MH096625 / MH / NIMH NIH HHS / United States |