Relationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy

TitleRelationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy
Publication TypeJournal Article
Year of Publication2006
AuthorsMonteiro de Almeida, S, Letendre, S, Zimmerman, J, Kolakowski, S, Lazzaretto, D, McCutchan, JA, Ellis, RJ
JournalJournal of Neuroimmunology
Volume179
Pagination180-5
Date Published2006
KeywordsAdult, Anti-Retroviral Agents, Cerebrospinal Fluid, Chemokine CCL2, Chemotaxis, Drug Administration Schedule, HIV Infections, Humans, Internal, Leukocyte, Leukocytosis, Male, Middle Aged
Abstract

Although monocyte chemoattractant protein (MCP-1)/CCL2 is believed to mediate trafficking of HIV-activated leukocytes into the CNS, its role has not been studied directly in humans. To evaluate MCP-1's effects on CNS leukocyte infiltration, we measured CSF leukocytes and MCP-1 levels in serial plasma and cerebrospinal fluid (CSF) samples from subjects who experienced large increases in viral load after interrupting antiretrovirals. Following large increases in CSF MCP-1, CSF leukocytosis (15-166 cells/microL) developed in 4 of 6 subjects. Both initial MCP-1 levels and subsequent changes were 3-fold larger in CSF than plasma. The magnitude and timing of changes suggested that MCP-1 triggers the development of CSF pleocytosis.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/16901548