Relationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | Relationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Monteiro de Almeida, S, Letendre, S, Zimmerman, J, Kolakowski, S, Lazzaretto, D, McCutchan, JA, Ellis, RJ |
Journal | Journal of Neuroimmunology |
Volume | 179 |
Pagination | 180-5 |
Date Published | 2006 |
Keywords | Adult, Anti-Retroviral Agents, Cerebrospinal Fluid, Chemokine CCL2, Chemotaxis, Drug Administration Schedule, HIV Infections, Humans, Internal, Leukocyte, Leukocytosis, Male, Middle Aged |
Abstract | Although monocyte chemoattractant protein (MCP-1)/CCL2 is believed to mediate trafficking of HIV-activated leukocytes into the CNS, its role has not been studied directly in humans. To evaluate MCP-1's effects on CNS leukocyte infiltration, we measured CSF leukocytes and MCP-1 levels in serial plasma and cerebrospinal fluid (CSF) samples from subjects who experienced large increases in viral load after interrupting antiretrovirals. Following large increases in CSF MCP-1, CSF leukocytosis (15-166 cells/microL) developed in 4 of 6 subjects. Both initial MCP-1 levels and subsequent changes were 3-fold larger in CSF than plasma. The magnitude and timing of changes suggested that MCP-1 triggers the development of CSF pleocytosis. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/16901548 |