Relationship between brain large artery characteristics and their downstream arterioles.

TitleRelationship between brain large artery characteristics and their downstream arterioles.
Publication TypeJournal Article
Year of Publication2018
AuthorsGutierrez, J, Murray, J, Chon, C, Morgello, S
JournalJ Neurovirol
Date Published2018 02
KeywordsAdult, Aged, Aged, 80 and over, Arterioles, Autopsy, Carotid Arteries, Case-Control Studies, Cerebral Arteries, Female, Frontal Lobe, Histocytochemistry, HIV Infections, Humans, Male, Middle Aged, Vascular Resistance, Vasodilation

We aimed to test the hypothesis that brain large artery diameters relate to distal downstream arteriolar diameters. In a sample of 110 autopsied individuals (69% men, 76% HIV+, mean age 51), we used multilevel models to relate large artery lumen and lumen-to-wall ratio to left frontal lobe arteriolar lumen and lumen-to-wall ratio adjusting for demographics and vascular risk factors. Comparing the large artery characteristics of the whole brain did not disclose significant associations with frontal lobe arteriolar characteristics. However, restricting the comparison to large arteries upstream of the studied arterioles demonstrated an independent association between left-sided frontal lobe arteriolar luminal diameter with large artery luminal diameters (B = 1.82 ± 0.77, P = 0.01) and with large artery lumen-to-wall ratio (B = 0.58 ± 0.29, P = 0.05). In stratified models, the point estimates in the HIV+ subsample were larger than in the HIV- subsample. These finding suggest coupling between higher proximal blood flow represented by large artery diameter and lower distal resistance represented by arteriolar dilatation. The relationship between arteriolar dilatation and brain parenchyma homeostasis should be further studied.

Alternate JournalJ Neurovirol
PubMed ID29256040
PubMed Central IDPMC5792319
Grant ListR25 MH080663 / MH / NIMH NIH HHS / United States
U24 MH100931 / MH / NIMH NIH HHS / United States
R25MH080663 / MH / NIMH NIH HHS / United States