Nuclear-Mitochondrial interactions influence susceptibility to HIV-associated neurocognitive impairment.

TitleNuclear-Mitochondrial interactions influence susceptibility to HIV-associated neurocognitive impairment.
Publication TypeJournal Article
Year of Publication2019
AuthorsSmieszek, S, Jia, P, Samuels, DC, Zhao, Z, Barnholtz-Sloan, JS, Kaur, H, Letendre, S, Ellis, RJ, Franklin, D, Hulgan, T, Kallianpur, AR, Bush, WS
Corporate AuthorsCHARTER Group
Date Published2019 05
KeywordsAIDS Dementia Complex, Cell Nucleus, CHARTER, Continental Population Groups, Genetic Association Studies, Haplotypes, HIV Infections, Humans, Internal, Mitochondria, Mitochondrial Proteins, Nuclear Proteins, Polymorphism, Single Nucleotide, Prospective Studies

HIV-associated neurocognitive impairment (NCI) is a term established to capture a wide spectrum of HIV related neurocognitive deficits ranging in severity from asymptomatic to dementia. The genetic underpinnings of this complex phenotype are incompletely understood. Mitochondrial function has long been thought to play a role in neurodegeneration, along with iron metabolism and transport. In this work, we aimed to characterize the interplay of mitochondrial DNA (mtDNA) haplogroup and nuclear genetic associations to NCI phenotypes in the CHARTER cohort, encompassing 1025 individuals of European-descent, African-descent, or admixed Hispanic. We first employed a polygenic modeling approach to investigate the global effect of previous marginally associated nuclear SNPs, and to examine how the polygenic effect of these SNPs is influenced by mtDNA haplogroups. We see evidence of a significant interaction between nuclear SNPs en masse and mtDNA haplogroups within European-descent and African-descent individuals. Subsequently, we performed an analysis of each SNP by mtDNA haplogroup, and detected significant interactions between two nuclear SNPs (rs17160128 and rs12460243) and European haplogroups. These findings, which require validation in larger cohorts, indicate a potential new role for nuclear-mitochondrial DNA interactions in susceptibility to NCI and shed light onto the pathophysiology of this neurocognitive phenotype.

Alternate JournalMitochondrion
PubMed ID30026132
PubMed Central IDPMC6336535
Grant ListHHSN271201000030C / MH / NIMH NIH HHS / United States
HHSN271201000036C / MH / NIMH NIH HHS / United States
N01 MH022005 / MH / NIMH NIH HHS / United States
R01 MH095621 / MH / NIMH NIH HHS / United States