Novel markers of oxidative stress in actively progressive HIV dementia

TitleNovel markers of oxidative stress in actively progressive HIV dementia
Publication TypeJournal Article
Year of Publication2004
AuthorsSacktor, N, Haughey, NJ, Cutler, R, Tamara, A, Turchan-Cholewo, J, Pardo, C, Vargas, D, Nath, A
JournalJournal of Neuroimmunology
Volume157
Issue1-2
Pagination176-84
Date Published12/2004
KeywordsBiological, External, Models
Abstract

Oxidative stress leads to the production of reactive oxygen species that can attack lipid membranes resulting in cellular dysfunction and death. Cellular redox state is closely linked to ceramide, sphingomyelin, and 4-hydroxynonenal (HNE) levels. We describe data showing increased levels of these oxidative stress markers in HIV encephalitis. In addition, actively progressing HIV dementia is associated with increases in HNE and ceramide, while inactive HIV dementia is associated with increases in sphingomyelin. These markers may be useful for distinguishing between different clinical phenotypes of HIV dementia.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/15579295