Home /A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.

A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.

Submitted by dcc on Fri, 01/08/2021 - 4:50pm
TitleA neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.
Publication TypeJournal Article
Year of Publication2018
AuthorsHellmuth, J, Milanini, B, Masliah, E, Tartaglia, MCarmela, Dunlop, MB, Moore, DJ, Javandel, S, DeVaughn, S, Valcour, V
JournalNeurocase
Volume24
Issue4
Pagination213-219
Date Published2018 08
ISSN1465-3656
KeywordsAged, 80 and over, AIDS Dementia Complex, Alzheimer Disease, Brain, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests
Abstract

We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.
DOI10.1080/13554794.2018.1530362
Alternate JournalNeurocase
PubMed ID30304986
PubMed Central IDPMC6226354
Grant ListK23 MH114724 / MH / NIMH NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
R01 MH113406 / MH / NIMH NIH HHS / United States
U24 MH100928 / MH / NIMH NIH HHS / United States