Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia |
Publication Type | Journal Article |
Year of Publication | 2003 |
Authors | Erichsen, D, Lopez, AL, Peng, H, Niemann, D, Williams, C, Bauer, M, Morgello, S, Cotter, RL, Ryan, LA, Ghorpade, A, Gendelman, HE, Zheng, JC |
Journal | Journal of Neuroimmunology |
Volume | 138 |
Issue | 1-2 |
Pagination | 144-55 |
Date Published | 05/2003 |
Keywords | Cells, Chemokine CX3CL1, Chemokines, Cultured, CX3C, External, Glutamic Acid, Recombinant Proteins, Virion |
Abstract | Fractalkine (FKN), a chemokine highly expressed in the central nervous system, participates in inflammatory responses operative in many brain disorders including HIV-1 associated dementia (HAD). In this report, HIV-1 progeny virions and pro-inflammatory products led to FKN production associated with neuronal injury and apoptosis. FKN was produced by neurons and astrocytes; but differentially produced by the two cell types. Laboratory tests paralleled those in infected people where cerebrospinal fluid FKN levels in HIV-1 infected cognitively impaired (n=16) patients were found to be increased when compared to infected patients without cognitive impairment (n=8, P=0.0345). These results demonstrate a possible role of FKN in HAD pathogenesis. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/12742664 |