Neurocognition in individuals co-infected with HIV and hepatitis C
Title | Neurocognition in individuals co-infected with HIV and hepatitis C |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Hinkin, CH, Castellon, SA, Levine, AJ, Barclay, TR, Singer, EJ |
Journal | Journal of Addictive Diseases |
Volume | 27 |
Pagination | 11-7 |
Date Published | 2008 |
Keywords | Adult, Antigens, Brain, CD4, Cognition Disorders, Comorbidity, Female, Hepatitis C, HIV Infections, Humans, Internal, Male, Neuropsychological Tests, Severity of Illness Index |
Abstract | Due to similar routes of viral transmission, many individuals infected with the human immunodeficiency virus (HIV) are also infected with the hepatitis C virus (HCV). Each virus can cause cognitive compromise among mono-infected individuals; evidence is accumulating that HIV/HCV co-infection may have a particularly deleterious impact on cognition. We present neuropsychological data obtained from 118 HIV+ adults with advanced HIV disease, 35 of whom were co-infected with HCV, who completed a comprehensive neurocognitive evaluation. Rates of global cognitive impairment were higher among co-infected patients than among those with HIV alone (63% vs. 43%). Within the specific domains of learning and memory, co-infected individuals were significantly more likely to be impaired than were the HIV mono-infected participants. Finally, we discuss implications of these findings and potential future directions for research in this area. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/18681187 |