Neurocognition in individuals co-infected with HIV and hepatitis C

TitleNeurocognition in individuals co-infected with HIV and hepatitis C
Publication TypeJournal Article
Year of Publication2008
AuthorsHinkin, CH, Castellon, SA, Levine, AJ, Barclay, TR, Singer, EJ
JournalJournal of Addictive Diseases
Date Published2008
KeywordsAdult, Antigens, Brain, CD4, Cognition Disorders, Comorbidity, Female, Hepatitis C, HIV Infections, Humans, Internal, Male, Neuropsychological Tests, Severity of Illness Index

Due to similar routes of viral transmission, many individuals infected with the human immunodeficiency virus (HIV) are also infected with the hepatitis C virus (HCV). Each virus can cause cognitive compromise among mono-infected individuals; evidence is accumulating that HIV/HCV co-infection may have a particularly deleterious impact on cognition. We present neuropsychological data obtained from 118 HIV+ adults with advanced HIV disease, 35 of whom were co-infected with HCV, who completed a comprehensive neurocognitive evaluation. Rates of global cognitive impairment were higher among co-infected patients than among those with HIV alone (63% vs. 43%). Within the specific domains of learning and memory, co-infected individuals were significantly more likely to be impaired than were the HIV mono-infected participants. Finally, we discuss implications of these findings and potential future directions for research in this area.