GluT4: A central player in hippocampal memory and brain insulin resistance.

TitleGluT4: A central player in hippocampal memory and brain insulin resistance.
Publication TypeJournal Article
Year of Publication2020
AuthorsMcNay, EC, Pearson-Leary, J
JournalExp Neurol
Volume323
Pagination113076
Date Published2020 01
ISSN1090-2430
KeywordsAnimals, Cognitive Dysfunction, Glucose Transporter Type 4, Hippocampus, Humans, Insulin Resistance, Memory
Abstract

Insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. Impairments to insulin signaling, such as those seen in type 2 diabetes and Alzheimer's disease, are associated with brain hypometabolism and cognitive impairment, but the mechanisms of insulin's central effects are not determined. Several lines of research converge to suggest that the insulin-responsive glucose transporter GluT4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance.

DOI10.1016/j.expneurol.2019.113076
Alternate JournalExp Neurol
PubMed ID31614121
PubMed Central IDPMC6936336
Grant ListR01 AG050598 / AG / NIA NIH HHS / United States
R01 DK077106 / DK / NIDDK NIH HHS / United States
HHSN271201000036C / MH / NIMH NIH HHS / United States
HHSN271201000030C / MH / NIMH NIH HHS / United States