Home /A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain

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TitleA functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain
Publication TypeJournal Article
Year of Publication2009
AuthorsYuferov, V, Ji, F, Nielsen, DA, Levran, O, Ho, A, Morgello, S, Shi, R, Ott, J, Kreek, MJ
JournalNeuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Volume34
Pagination1185-1197
Date Published2009
KeywordsAfrican Americans, Alcohol-Related Disorders, Brain, Cocaine-Related Disorders, Enkephalins, European Continental Ancestry Group, External, Gene Expression, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Polymorphism, Single Nucleo
Abstract

{Dynorphin peptides and the kappa-opioid receptor are important in the rewarding properties of cocaine, heroin, and alcohol. We tested polymorphisms of the prodynorphin gene (PDYN) for association with cocaine dependence and cocaine/alcohol codependence. We genotyped six single nucleotide polymorphisms (SNPs), located in the promoter region, exon 4 coding, and 3' untranslated region, in 106 Caucasians and 204 African Americans who were cocaine dependent, cocaine/alcohol codependent, or controls. In Caucasians, we found point-wise significant associations of 3'UTR SNPs (rs910080, rs910079, and rs2235749) with cocaine dependence and cocaine/alcohol codependence. These SNPs are in high linkage disequilibrium, comprising a haplotype block. The haplotype CCT was significantly experiment-wise associated with cocaine dependence and with combined cocaine dependence and cocaine/alcohol codependence (false discovery rate
URLhttp://www.ncbi.nlm.nih.gov/pubmed/18923396