Home /Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.

Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.

Submitted by dcc on Thu, 11/19/2015 - 3:25pm
TitleExpression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.
Publication TypeJournal Article
Year of Publication2014
AuthorsHolder, GE, McGary, CM, Johnson, EM, Zheng, R, John, VT, Sugimoto, C, Kuroda, MJ, Kim, W-K
JournalJ Neuroimmune Pharmacol
Volume9
Issue5
Pagination716-26
Date Published2014 Dec
ISSN1557-1904
KeywordsAnimals, Encephalitis, External, Gene Expression Regulation, Viral, HIV Infections, HIV-1, Humans, Lectins, C-Type, Macaca mulatta, Macrophages, Male, Mannose-Binding Lectins, Phenotype, Receptors, Cell Surface, Simian Acquired Immunodeficiency Syndrome, Simian immunodeficiency virus
Abstract

We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS.
DOI10.1007/s11481-014-9564-y
Alternate JournalJ Neuroimmune Pharmacol
PubMed ID25146376
PubMed Central IDPMC4364002
Grant ListR01 AI097059 / AI / NIAID NIH HHS / United States
R01AI097059 / AI / NIAID NIH HHS / United States
R21 AI091501 / AI / NIAID NIH HHS / United States
R21 AI110163 / AI / NIAID NIH HHS / United States
R21AI091501 / AI / NIAID NIH HHS / United States
R21AI110163 / AI / NIAID NIH HHS / United States
R24 MH059724 / MH / NIMH NIH HHS / United States
R24MH59724 / MH / NIMH NIH HHS / United States