Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Duncan, R, Shapshak, P, Page, JB, Chiappelli, F, McCoy, CB, Messiah, SE |
Journal | Frontiers in Bioscience: A Journal and Virtual Library |
Volume | 12 |
Pagination | 1488-95 |
Date Published | 2007 |
Keywords | Adult, African Americans, CD4 Lymphocyte Count, Crack Cocaine, Disease Progression, External, Female, HIV Infections, HIV-1, Humans, RNA, Viral, Viral Load |
Abstract | This study reports on the role of cocaine as effect modifier of the association of CD4+ cell counts and RNA viral load. HIV-1 seropositive (n = 80) and seronegative (n = 42) African American women (AAW) crack cocaine smokers were recruited. Increasing cocaine use, based on self-reports and laboratory values, significantly exacerbates the immunopathology of HIV-1 in a dose-response manner, confirmed by a non-linear drop in CD4+ cell number for a given viral load in HIV+ AAW. This report supports a view of deleterious effects due to cocaine use in humans. |
URL | http://www.ncbi.nlm.nih.gov/pubmed/17127396 |