Home /CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

Submitted by dcc on Wed, 04/23/2014 - 7:47am
TitleCCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults
Publication TypeJournal Article
Year of Publication2004
AuthorsSingh, K, Ellis, RJ, Marquie-Beck, J, Letendre, S, Heaton, RK, Grant, I, Spector, SA
JournalJournal of Neuroimmunology
Volume157
Issue1-2
Pagination185-92
Date Published12/2004
KeywordsCCR2, CCR5, Chemokine, Genetic, Internal, Polymorphism, Receptors
Abstract

CCR2 is a minor coreceptor for human immune deficiency virus-1 (HIV-1) and its impact on HIV-1-related neuropsychological impairment (NPI) remains unknown. We studied the impact of CCR2-V64I polymorphisms on the development of NPI in 121 HIV-1 patients. The CCR2-64-I allele was associated with rate of progression to NPI when measured from the first study visit (Log Rank p=0.01) or from the estimated time of seroconversion (p=0.02). CCR2-V64I was not associated with plasma or CSF HIV-1 RNA load, suggesting that the impact of CCR2 on neuropathogenesis may involve alterations in inflammatory responses within the CNS rather than a direct impact on viral entry or replication.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/15579296