Better executive function is independently associated with full HIV suppression during combination therapy.

TitleBetter executive function is independently associated with full HIV suppression during combination therapy.
Publication TypeJournal Article
Year of Publication2019
AuthorsAnderson, AM, Pérez-Santiago, J, Zheng, Z, Huang, E, Franklin, D, Iudicello, J, Moore, D, Ellis, RJ, Heaton, RK, Letendre, S
JournalAIDS
Volume33
Issue15
Pagination2309-2316
Date Published2019 12 01
ISSN1473-5571
KeywordsCHARTER, Internal
Abstract

OBJECTIVE: HIV-associated neurocognitive impairment continues to be prevalent and clinically relevant. We examined the relationship between neurocognition and full plasma HIV RNA suppression among study participants over a 15-year period at a large research program.DESIGN/METHODS: We analyzed the combined prospective studies of the HIV Neurobehavioral Research Program at the University of California at San Diego. Participants were eligible for analysis if on three drug combination antiretroviral therapy with comprehensive neuropsychological testing results. Participants who reported recent nonadherence were excluded. The primary outcome was plasma HIV RNA of 50 copies/ml or less. Generalized estimating equation was used to assess for associations with full virologic suppression taking into account longitudinal visits.RESULTS: There were 1943 participants at baseline, of whom 69.4% had plasma HIV RNA of 50 copies/ml or less. Participants with full suppression were slightly older, less likely to abuse cocaine, and had significantly better executive function. Multivariate analysis with incorporation of longitudinal visits (total = 5555) confirmed current cocaine abuse to be strongly associated with lack of virologic suppression (odds ratio = 0.45, 95% confidence interval = 0.31-0.63). In contrast, increasing age, increasing years of HIV infection, and increasing executive function (odds ratio = 1.18 for T score change of 10, 95% confidence interval = 1.07-1.30) were associated with full virologic suppression. Lack of virologic suppression at baseline was associated with a significant subsequent decline in executive function.CONCLUSION: In a 15-year research cohort of almost 2000 HIV-infected individuals on combination antiretroviral therapy, better executive function was associated with full virologic suppression, possibly as a result rather than a cause.

DOI10.1097/QAD.0000000000002348
Alternate JournalAIDS
PubMed ID31764096
PubMed Central IDPMC6905116
Grant ListK23 MH095679 / MH / NIMH NIH HHS / United States
R01 AG062387 / AG / NIA NIH HHS / United States
R21 MH118092 / MH / NIMH NIH HHS / United States
R25 MH108389 / MH / NIMH NIH HHS / United States
R01 MH107345 / MH / NIMH NIH HHS / United States
K24 MH097673 / MH / NIMH NIH HHS / United States