Alzheimer's Disease Pathology in Middle Aged and Older People with HIV: Comparisons with Non-HIV Controls on a Healthy Aging and Alzheimer's Disease Trajectory and Relationships with Cognitive Function.
Title | Alzheimer's Disease Pathology in Middle Aged and Older People with HIV: Comparisons with Non-HIV Controls on a Healthy Aging and Alzheimer's Disease Trajectory and Relationships with Cognitive Function. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Sundermann, EE, Campbell, LM, Villers, O, Bondi, MW, Gouaux, B, Salmon, DP, Galasko, D, Soontornniyomkij, V, Ellis, RJ, Moore, DJ |
Journal | Viruses |
Volume | 15 |
Issue | 6 |
Date Published | 2023 Jun 04 |
ISSN | 1999-4915 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Cognition, Female, Healthy Aging, Humans, Middle Aged, tau Proteins |
Abstract | We determined the prevalence of Alzheimer's disease (AD) pathological hallmarks, amyloid-β and phosphorylated-Tau, in autopsied brains of 49 people with HIV (PWH) (ages: 50-68; mean age = 57.0) from the National NeuroAIDS Tissue Consortium and in a comparative cohort of 55 people without HIV (PWoH) from the UC San Diego Alzheimer's Disease Research Center (17 controls, 14 mild cognitive impairment, 24 AD; ages: 70-102, mean age = 88.7). We examined how AD pathology relates to domain-specific cognitive functions in PWH overall and in sex-stratified samples. Amyloid-β and phosphorylated-Tau positivity (presence of pathology of any type/density) was determined via immunohistochemistry in AD-sensitive brain regions. Among PWH, amyloid-β positivity ranged from 19% (hippocampus) to 41% (frontal neocortex), and phosphorylated-Tau positivity ranged from 47% (entorhinal cortex) to 73% (transentorhinal cortex). Generally, AD pathology was significantly less prevalent, and less severe when present, in PWH versus PWoH regardless of cognitive status. Among PWH, positivity for AD pathology related most consistently to memory-related domains. Positivity for p-Tau pathology related to memory-related domains in women with HIV only, although the sample size of women with HIV was small ( = 10). Results indicate that AD pathology is present in a sizable portion of middle aged and older PWH, although not to the extent in older PWoH. Studies with better age-matched PWoH are needed to examine the effect of HIV status on AD pathology. |
DOI | 10.3390/v15061319 |
Alternate Journal | Viruses |
PubMed ID | 37376619 |
PubMed Central ID | PMC10305373 |
Grant List | HHSN271201000030C / MH / NIMH NIH HHS / United States N01 MH22005 / NH / NIH HHS / United States P30 AG062429 / AG / NIA NIH HHS / United States RF1AG061070 / NH / NIH HHS / United States P30MH062512 / NH / NIH HHS / United States R01 MH096648 / MH / NIMH NIH HHS / United States N01MH22005 / MH / NIMH NIH HHS / United States RF1 AG061070 / AG / NIA NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States R25MH081482 / NH / NIH HHS / United States R01AG049810 / NH / NIH HHS / United States R01MH096648 / NH / NIH HHS / United States P30-AG062429 / NH / NIH HHS / United States U24 MH100928 / NH / NIH HHS / United States R01 AG049810 / AG / NIA NIH HHS / United States HHSN271201000036C / NH / NIH HHS / United States PSTHN71 / NH / NIH HHS / United States U24 MH100928 / MH / NIMH NIH HHS / United States R25 MH081482 / MH / NIMH NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States |