Date Published:
02/2013

Publication Type:
Journal Article

Authors:

R.P. Fellows
D. Byrd
S. Morgello
M.H.I.V.B. Bank

Secondary:
Journal of the International Neuropsychological Society (JINS)

Volume:
19

Pagination:
216-225

Issue:
2

URL:
https://pubmed.ncbi.nlm.nih.gov/

DOI:
10.1017/S1355617712001245

Keywords:
Acquired Immunodeficiency Syndrome;Cognition;Cognitive complaints;Depression;Internal;Mood disorders;Neuropsychological Tests

Abstract:
<p>Major depressive disorder (MDD), cognitive symptoms, and mild cognitive deficits commonly occur in HIV-infected individuals, despite highly active antiretroviral therapies. In this study, we compared neuropsychological performance and cognitive symptoms of 191 HIV-infected participants. Results indicated that participants with a formal diagnosis of current MDD performed significantly worse than participants without MDD in all seven neuropsychological domains evaluated, with the largest effect sizes in information processing speed, learning, and memory. In addition, a brief assessment of cognitive symptoms, derived from a comprehensive neuromedical interview, correlated significantly with neurocognitive functioning. Participants with MDD reported more cognitive symptoms and showed greater neurocognitive deficits than participants without MDD. These findings indicate that HIV-infected adults with MDD have more cognitive symptoms and worse neuropsychological performance than HIV-infected individuals without MDD. The results of this study have important implications for the diagnosis of HIV-associated neurocognitive disorders (HAND).</p>