Date Published:
08/2019

Publication Type:
Journal Article

Authors:

R. Saloner
M.J. Marquine
E.E. Sundermann
S. Hong
J.A. McCutchan
R.J. Ellis
R.K. Heaton
I. Grant
M. Cherner

Secondary:
Journal of Acquired Immune Deficiency Syndromes

Volume:
81

URL:
https://pubmed.ncbi.nlm.nih.gov/

Keywords:
Internal

Abstract:
<p>The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Among persons living with HIV, Val carriers<br />display neurocognitive deficits relative to Met carriers, presumably due to exacerbation of HIV-related depletion of DA. COMT may also impact neurocognition by modulating cardiometabolic function, which is often dysregulated among persons<br />living with HIV. We examined the interaction of COMT, cardiometabolic risk, and nadir CD4 on neurocognitive impairment (NCI) among HIV+ men.<br /> </p>