Date Published:
2017 Jan 01
Publication Type:
Journal Article
Authors:
Secondary:
J Infect Dis
Volume:
215
Pagination:
105-113
Issue:
1
PMID:
27789723
URL:
https://pubmed.ncbi.nlm.nih.gov/27789723
Keywords:
Adult;Anti-HIV Agents;CD4 Lymphocyte Count;Female;HIV Infections;HIV-1;Humans;Male;Middle Aged;neurocognitive disorders;Prevalence;RNA, Viral;Viral Load
Abstract:
<p>BACKGROUND: Neurocognitive disorders remain common among human immunodeficiency virus (HIV)-positive adults, perhaps owing to persistent HIV-1 RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART).METHODS: Using a single-copy assay, we measured HIV-1 RNA levels in CSF and plasma specimens from 220 HIV-positive adults who were taking suppressive ART. Fifty-five participants were tested twice.RESULTS: HIV-1 RNA was detected in 42.3% of CSF and 65.2% of plasma samples. Correlates of higher CSF HIV-1 RNA levels included higher nadir and current CD4 T-cell counts, a plasma HIV-1 RNA level of ≥ 1 copy/mL, and a lower central nervous system penetration-effectiveness score (model P < .001). Worse neurocognitive performance was associated with discordance in HIV-1 RNA detection between plasma and CSF, lower overall CSF HIV-1 RNA level, and longer ART duration, among others (model P < .001). In the longitudinal subgroup, CSF HIV-1 RNA persisted in most participants (69%) over 7 months.CONCLUSIONS: Low-level HIV-1 RNA in CSF is common during suppressive ART and is associated with low-level HIV-1 RNA in blood, better immune status, and lower ART drug distribution into CSF. The association between HIV-1 RNA discordance and HIV-associated neurocognitive disorder (HAND) may reflect compartmentalization. The relationship between HAND, lower HIV-1 RNA levels in CSF, and lower CD4 T-cell counts may reflect disturbances in the immune response to HIV-1 in the CNS.</p>