Date Published:
2016

Publication Type:
Journal Article

Authors:

P.L. Fazeli
D.J. Moore
D.R. Franklin
A. Umlauf
R.K. Heaton
A.C. Collier
C.M. Marra
D.B. Clifford
B.B. Gelman
N.C. Sacktor
S. Morgello
D.M. Simpson
J.A. McCutchan
I. Grant
S.L. Letendre

Secondary:
Curr HIV Res

Volume:
14

Pagination:
324-30

Issue:
4

PMID:
26673902

URL:
https://pubmed.ncbi.nlm.nih.gov/26673902

DOI:
10.2174/1570162x14666151221145926

Keywords:
Adult;AIDS Dementia Complex;Amyloid beta-Peptides;Cerebrospinal Fluid;Cross-Sectional Studies;Dementia;Female;HIV Infections;Humans;Male;Middle Aged

Abstract:
<p>BACKGROUND: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients.OBJECTIVE: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).METHODS: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.RESULTS: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).CONCLUSION: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.</p>