Date Published:
2021 Feb

Publication Type:
Journal Article

Authors:

R. Saloner
E.W. Paolillo
R.K. Heaton
D.J. Grelotti
M.B. Stein
A.H. Miller
H. Atkinson
S.L. Letendre
R.J. Ellis
I. Grant
J.E. Iudicello
D.J. Moore

Secondary:
J Neurovirol

Volume:
27

Pagination:
160-167

Issue:
1

PMID:
33405198

URL:
https://pubmed.ncbi.nlm.nih.gov/33405198

DOI:
10.1007/s13365-020-00925-1

Keywords:
CHARTER;Internal

Abstract:
<p>We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae.</p>