Date Published:
2014 Dec

Publication Type:
Journal Article

Authors:

G.E. Holder
C.M. McGary
E.M. Johnson
R. Zheng
V.T. John
C. Sugimoto
M.J. Kuroda
W.K. Kim

Secondary:
J Neuroimmune Pharmacol

Volume:
9

Pagination:
716-26

Issue:
5

PMID:
25146376

URL:
https://pubmed.ncbi.nlm.nih.gov/25146376

DOI:
10.1007/s11481-014-9564-y

Keywords:
Animals;Encephalitis;External;Gene Expression Regulation, Viral;HIV Infections;HIV-1;Humans;Lectins, C-Type;Macaca mulatta;Macrophages;Male;Mannose-Binding Lectins;Phenotype;Receptors, Cell Surface;Simian Acquired Immunodeficiency Syndrome;Simian immunodeficiency virus

Abstract:
<p>We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injection of liposome-encapsulated bisphosphonates eliminated CD206-expressing cells in the brain, confirming their perivascular location and phagocytic capacity. In vivo labeling with bromodeoxyuridine in normal uninfected and SIV-infected macaques in combination with CD206 immunostaining revealed a CD206+-to-CD206- shift within pre-existing PVM during SIV brain infection and neuroinflammation. These findings identify CD206 as a unique marker of human and macaque PVM, and underscore the utility of this marker in studying the origin, turnover and functions of these cells in AIDS.</p>