Date Published:
2023 Oct

Publication Type:
Journal Article

Authors:

Thomas A Angelovich
Catherine R Cochrane
Jingling Zhou
Carolin Tumpach
Sarah J Byrnes
Janna Jamal Eddine
Emily Waring
Kathleen Busman-Sahay
Claire Deleage
Trisha A Jenkins
Anna C Hearps
Stuart Turville
Paul R Gorry
Sharon R Lewin
Bruce J Brew
Jacob D Estes
Michael Roche
Melissa J Churchill

PMID:
37493435

URL:
https://pubmed.ncbi.nlm.nih.gov/37493435/

DOI:
10.1002/ana.26750

Abstract:
Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy.