Date Published:
04/2000
Publication Type:
Journal Article
Authors:
Secondary:
CNS Spectrums
Volume:
5
Pagination:
31-42
Issue:
4
URL:
https://pubmed.ncbi.nlm.nih.gov/
Keywords:
External
Abstract:
<p>Infection with human immunodeficiency virus type 1 (HIV-1) leads rapidly to infection of the brain and subsequent neuropsychological impairment, including subclinical impairment, minor cognitive-motor disorder, and HIV-1-associated dementia (HAD). This article reviews HAD and the factors involved in its pathogenesis; the effectiveness of antiretroviral therapy; the prevalence of HIV-1 and subtypes; and the role of chemokines and cytokines as the capstones associated with neuropathology due to inflammation.</p>