Date Published:
05/2003

Publication Type:
Journal Article

Authors:

D. Erichsen
A.L. Lopez
H. Peng
D. Niemann
C. Williams
M. Bauer
S. Morgello
R.L. Cotter
L.A. Ryan
A. Ghorpade
H.E. Gendelman
J.C. Zheng

Secondary:
Journal of Neuroimmunology

Volume:
138

Pagination:
144-55

Issue:
1-2

URL:
https://pubmed.ncbi.nlm.nih.gov/

Keywords:
Cells;Chemokine CX3CL1;Chemokines;Cultured;CX3C;External;Glutamic Acid;Recombinant Proteins;Virion

Abstract:
<p>Fractalkine (FKN), a chemokine highly expressed in the central nervous system, participates in inflammatory responses operative in many brain disorders including HIV-1 associated dementia (HAD). In this report, HIV-1 progeny virions and pro-inflammatory products led to FKN production associated with neuronal injury and apoptosis. FKN was produced by neurons and astrocytes; but differentially produced by the two cell types. Laboratory tests paralleled those in infected people where cerebrospinal fluid FKN levels in HIV-1 infected cognitively impaired (n=16) patients were found to be increased when compared to infected patients without cognitive impairment (n=8, P=0.0345). These results demonstrate a possible role of FKN in HAD pathogenesis.</p>