Date Published:
12/2005
Publication Type:
Journal Article
Authors:
Secondary:
Journal of Neuroimmunology
Volume:
169
Pagination:
144-52
Issue:
1-2
URL:
https://pubmed.ncbi.nlm.nih.gov/
Keywords:
Internal;RNA;Viral
Abstract:
<p><strong>BACKGROUND:</strong> Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS. <strong>METHODS:</strong> MCP-1 and HIV viral load (VL) were measured in serially obtained samples of plasma and cerebrospinal fluid (CSF) in subjects either interrupting (TI) or starting (TS) antiretroviral therapy. <strong>RESULTS: </strong>Following TI, plasma VL rebounded first, followed by increases in CSF MCP-1, which immediately preceded or coincided with a rebound of CSF VL. <strong>CONCLUSION: </strong>The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other.</p>