Date Published:
03/2019

Publication Type:
Journal Article

Authors:

R. Saloner
L.M. Campbell
V. Serrano
J.L. Montoya
E. Pasipanodya
E.W. Paolillo
D. Franklin
R.J. Ellis
S. Letendre
A.C. Collier
D.B. Clifford
B. Gelman
C. Marra
J.A. McCutchan
S. Morgello
N. Sacktor
D.V. Jeste
I. Grant
R.K. Heaton
D. Moore
CHARTER Group
HNRP Group

Secondary:
Journal of the International Neuropsychological Society

URL:
https://pubmed.ncbi.nlm.nih.gov/

Keywords:
CHARTER;Internal

Abstract:
<p>Studies of neurocognitively elite older adults, termed SuperAgers, have identified clinical predictors and neurobiological indicators of resilience against age-related neurocognitive decline. Despite rising rates of older persons<br />living with HIV (PLWH), SuperAging (SA) in PLWH remains undefined. We aimed to establish neuropsychological criteria for SA in PLWH and examined clinically relevant correlates of SA. Methods: 734 PLWH and 123 HIV-uninfected<br />participants between 50 and 64 years of age underwent neuropsychological and neuromedical evaluations. SA was defined as demographically corrected (i.e., sex, race/ethnicity, education) global neurocognitive performance within normal range for 25-year-olds. Remaining participants were labeled cognitively normal (CN) or impaired (CI) based on actual age. Chi-square and analysis of variance tests examined HIV group differences on neurocognitive status and demographics. Within PLWH, neurocognitive status differences were tested on HIV disease characteristics, medical comorbidities, and everyday functioning. Multinomial logistic regression explored independent predictors of neurocognitive status.<br /> </p>