Date Published:
2011 Summer

Publication Type:
Journal Article

Authors:

D.J. Moore
M. Arce
S. Moseley
A. McCutchan
J. Marquie-Beck
D.R. Franklin
F. Vaida
C.L. Achim
J. McArthur
S. Morgello
D.M. Simpson
B.B. Gelman
A.C. Collier
C.M. Marra
D.B. Clifford
R.K. Heaton
I. Grant

Secondary:
J Neuropsychiatry Clin Neurosci

Volume:
23

Pagination:
316-23

Issue:
3

PMID:
21948893

URL:
https://pubmed.ncbi.nlm.nih.gov/21948893

DOI:
10.1176/appi.neuropsych.23.3.316

Keywords:
Adult;CD4 Lymphocyte Count;CHARTER;Cognition Disorders;Executive function;Family Health;Female;HIV Infections;Humans;Internal;Male;Middle Aged;Motor Skills;Neuropsychological Tests;Predictive Value of Tests;Verbal Behavior

Abstract:
<p>HIV-negative individuals with a family history of dementia (FHD) are more likely to develop dementia than those without FHD. Whether FHD increases risk for neuropsychological (NP) impairment in HIV+ persons is unknown. As part of a multisite study into HIV-associated neurocognitive disorders (HAND), the authors captured FHD with a free-response, self-report question, and assessed NP performance with a comprehensive battery of tests. The authors examined HIV+ persons with (N=190) and without (N=916) self-reported FHD. Despite the fact that the FHD group had factors typically associated with better NP performance (e.g., higher CD4 counts and estimated verbal IQ), persons with FHD had significantly worse NP ability than those without FHD as measured by a Global Deficit Score. Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study.</p>