Date Published:
2020 01

Publication Type:
Journal Article

Authors:

E.C. McNay
J. Pearson-Leary

Secondary:
Exp Neurol

Volume:
323

Pagination:
113076

PMID:
31614121

URL:
https://pubmed.ncbi.nlm.nih.gov/31614121

DOI:
10.1016/j.expneurol.2019.113076

Keywords:
Animals;CHARTER;Cognitive Dysfunction;Glucose Transporter Type 4;Hippocampus;Humans;Insulin Resistance;Internal;Memory;Short-Term

Abstract:
<p>Insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. Impairments to insulin signaling, such as those seen in type 2 diabetes and Alzheimer's disease, are associated with brain hypometabolism and cognitive impairment, but the mechanisms of insulin's central effects are not determined. Several lines of research converge to suggest that the insulin-responsive glucose transporter GluT4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance.</p>