Date Published:
2014 Jun

Publication Type:
Journal Article

Authors:

J. Harezlak
R. Cohen
A. Gongvatana
M. Taylor
S. Buchthal
G. Schifitto
J. Zhong
E.S. Daar
J.R. Alger
M. Brown
E.J. Singer
T.B. Campbell
D. McMahon
Y.T. So
C.T. Yiannoutsos
B.A. Navia

Secondary:
J Neurovirol

Volume:
20

Pagination:
294-303

Issue:
3

PMID:
24696364

URL:
https://pubmed.ncbi.nlm.nih.gov/24696364

DOI:
10.1007/s13365-014-0246-6

Keywords:
Adult;AIDS Dementia Complex;Anti-Retroviral Agents;Aspartic Acid;Basal Ganglia;Choline;Chronic Disease;Creatine;External;Female;Frontal Lobe;Gray Matter;Humans;Longitudinal Studies;Magnetic Resonance Spectroscopy;Male;Middle Aged;Predictive Value of Tests;Protons;White Matter

Abstract:
<p>The reasons for persistent brain dysfunction in chronically HIV-infected persons on stable combined antiretroviral therapies (CART) remain unclear. Host and viral factors along with their interactions were examined in 260 HIV-infected subjects who underwent magnetic resonance spectroscopy (MRS). Metabolite concentrations (NAA/Cr, Cho/Cr, MI/Cr, and Glx/Cr) were measured in the basal ganglia, the frontal white matter, and gray matter, and the best predictive models were selected using a bootstrap-enhanced Akaike information criterion (AIC). Depending on the metabolite and brain region, age, race, HIV RNA concentration, ADC stage, duration of HIV infection, nadir CD4, and/or their interactions were predictive of metabolite concentrations, particularly the basal ganglia NAA/Cr and the mid-frontal NAA/Cr and Glx/Cr, whereas current CD4 and the CPE index rarely or did not predict these changes. These results show for the first time that host and viral factors related to both current and past HIV status contribute to persisting cerebral metabolite abnormalities and provide a framework for further understanding neurological injury in the setting of chronic and stable disease.</p>