Date Published:
2022 Jun
Publication Type:
Journal Article
Authors:
Secondary:
AIDS Behav
Volume:
26
Pagination:
1966-1979
Issue:
6
PMID:
34878634
URL:
https://pubmed.ncbi.nlm.nih.gov/34878634
DOI:
10.1007/s10461-021-03546-9
Keywords:
CHARTER;Internal
Abstract:
<p>Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1-5 years of follow-up. Classes were defined using 'peak-age' global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1 (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2 (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3 (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1 included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health.</p>