Date Published:
2023 Mar 17

Publication Type:
Journal Article

Authors:

S.B. Joseph
S. Gianella
T.H. Burdo
P. Cinque
M. Gisslén
S. Letendre
A. Nath
S. Morgello
L.C. Ndhlovu
S. Spudich

Secondary:
J Infect Dis

Volume:
227

Pagination:
S3-S15

Issue:
Suppl 1

PMID:
36930640

URL:
https://pubmed.ncbi.nlm.nih.gov/36930640

DOI:
10.1093/infdis/jiac370

Keywords:
Central Nervous System;Central Nervous System Diseases;Cognitive Dysfunction;HIV Infections;HIV-1;Humans

Abstract:
<p>Despite viral suppression with antiretroviral therapy (ART), people with human immunodeficiency virus (HIV) continue to experience central nervous system (CNS) complications, primarily in the form of mild cognitive impairment and mental health disorders (eg, depression, anxiety, other neuropsychiatric problems). The multifactorial pathogenesis and heterogeneity of mechanisms likely underlying CNS complications must be addressed in the development of preventive interventions and effective treatments. The biotyping approach has previously been useful to define phenotypes of other CNS diseases based on underlying mechanisms and could be translated to the field of neuroHIV. The purpose of the Biotype Workshop series, and the Virology, Immunology and Neuropathology Working Group in particular, is to capitalize on current and new technologies and guide future research efforts using the wealth of available immunological, virologic, and neuropathological data collected from people with HIV on and off ART.</p>