Date Published:
2006
Publication Type:
Journal Article
Authors:
Secondary:
Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Volume:
19
Pagination:
217-21
URL:
https://pubmed.ncbi.nlm.nih.gov/
Keywords:
Adult;Axons;Biological Markers;Chemokine CCL2;Female;Fibroblast Growth Factor 1;HIV Infections;HIV-1;Humans;Immunoglobulin G;Internal;Macrophages;Male;Memory;Memory Disorders;Middle Aged;Receptors;RNA;Statis;Tumor Necrosis Factor;Viral
Abstract:
<p>OBJECTIVE: To use clinical specimens to better understand the neuropathogenesis of prospective memory (ProM) functioning in persons with HIV-1 infection. BACKGROUND: Emergent evidence suggests that HIV-1 is associated with impaired ProM, but the underlying neuropathophysiology of this deficit is not known. METHODS: Thirty-five nondemented subjects with HIV-1 infection completed measures of both ProM (ie, memory for future intentions) and retrospective memory (RM; ie, memory for past episodes). A panel of biomarkers reflecting several possible neuropathogenic mechanisms of HIV was measured in plasma and cerebrospinal fluid, including HIV-1 RNA, total tau, monocyte chemoattractant protein-1 (MCP-1), soluble receptor for tumor necrosis factor type II, and fibroblast growth factor 1. RESULTS: After controlling for antiretroviral therapy and CD4 lymphocyte count, higher levels of MCP-1 in plasma, and soluble receptor for tumor necrosis factor type II and tau in cerebrospinal fluid were associated with ProM, but not RM. Markers of astrocytosis, growth factor depletion, and HIV-1 replication did not predict either ProM or RM. CONCLUSIONS: ProM impairment in HIV-1 may be dissociable from RM, perhaps reflecting specific neuropathogenic mechanisms of macrophage activation and axonal injury.</p>