Date Published:
2015 Aug

Publication Type:
Journal Article

Authors:

P.L. Fazeli
M.J. Marquine
C. Dufour
B.L. Henry
J.L. Montoya
B. Gouaux
R.C. Moore
S. Letendre
S.Paul Woods
I. Grant
D.V. Jeste
D. Moore

Secondary:
AIDS Behav

Volume:
19

Pagination:
1470-7

Issue:
8

PMID:
25731660

URL:
https://pubmed.ncbi.nlm.nih.gov/25731660

DOI:
10.1007/s10461-015-1024-z

Keywords:
Activities of Daily Living;Aged;Aging;CHARTER;Cognition Disorders;Cross-Sectional Studies;Exercise;Female;HIV Infections;Humans;Internal;Longitudinal Studies;Male;Middle Aged;Motor Activity;Neuropsychological Tests;Surveys and Questionnaires

Abstract:
<p>We examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. One hundred older HIV+ adults completed the International Physical Activity Questionnaire, a neurocognitive battery, and IADL scale. Higher levels of moderate PA were associated with lower odds of NCI (p = 0.01), even when covariates were modeled. The association between moderate PA and NCI was driven by executive function (p = 0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p = 0.03), although this fell to a trend (p = 0.08) when including covariates. Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither (p = 0.03). While these cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning in older HIV+ adults, longitudinal studies utilizing objective PA methods are needed to evaluate directionality and mechanisms.</p>