Date Published:
2017 06 19

Publication Type:
Journal Article

Authors:

C. Ubaida-Mohien
B. Lamberty
A.M. Dickens
M.M. Mielke
T.D. Marcotte
N. Sacktor
I. Grant
S. Letendre
D. Franklin
P. Cibrowski
R. Tharakan
J.C. McArthur
H.S. Fox
N.J. Haughey

Secondary:
AIDS

Volume:
31

Pagination:
1365-1378

Issue:
10

PMID:
28574961

URL:
https://pubmed.ncbi.nlm.nih.gov/28574961

DOI:
10.1097/QAD.0000000000001503

Keywords:
Acute-Phase Reaction;Adult;AIDS Dementia Complex;Cerebrospinal Fluid;CHARTER;Complement System Proteins;Computational Biology;Female;HIV Infections;Humans;Internal;Longitudinal Studies;Male;Prognosis;Proteome

Abstract:
<p>BACKGROUND: The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified.METHOD: In this study, we used systems informatics to interrogate the cerebrospinal fluid proteomic content of longitudinal samples obtained from HIV-infected adults with stably unimpaired, stably impaired, worsening, or improving neurocognitive performance.RESULTS AND CONCLUSION: The patterns of change in cerebrospinal fluid protein content implicated the induction of acute phase and complement systems as important regulators of neurocognitive status. Worsening neurocognitive performance was preceded by induction of acute phase and complement systems, whereas improving neurocognitive performance was preceded by a downregulation of these systems.</p>