Date Published:
2011 Mar

Publication Type:
Journal Article

Authors:

K. Lin
M.J. Taylor
R. Heaton
D. Franklin
T. Jernigan
C. Fennema-Notestine
A. McCutchan
H. Atkinson
R.J. Ellis
J. McArthur
S. Morgello
D. Simpson
A.C. Collier
C. Marra
B. Gelman
D. Clifford
I. Grant

Secondary:
J Clin Exp Neuropsychol

Volume:
33

Pagination:
326-34

Issue:
3

PMID:
21229435

URL:
https://pubmed.ncbi.nlm.nih.gov/21229435

DOI:
10.1080/13803395.2010.518140

Keywords:
Adult;Aspartic Acid;Brain Injuries;Cognition Disorders;Depression;Executive function;Female;HIV Infections;Humans;Magnetic Resonance Spectroscopy;Male;Memory, Short-Term;Middle Aged;Neuropsychological Tests;Psychiatric Status Rating Scales;Substance-Related Disorders

Abstract:
<p>We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.</p>