The role of decision-making ability in HIV/AIDS: impact on prospective memory.
Title | The role of decision-making ability in HIV/AIDS: impact on prospective memory. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Coulehan, K, Byrd, D, Arentoft, A, Monzones, J, Fuentes, A, Fraser, F, Rosario, A, Morgello, S, Mindt, MRivera |
Journal | J Clin Exp Neuropsychol |
Volume | 36 |
Issue | 7 |
Pagination | 730-41 |
Date Published | 2014 |
ISSN | 1744-411X |
Keywords | Acquired Immunodeficiency Syndrome, Adult, Decision Making, Executive function, Female, Humans, Internal, Male, Memory, Episodic, Middle Aged |
Abstract | BACKGROUND: Prospective memory (ProM), a form of episodic memory related to execution of future intentions, is important for everyday functioning. Among persons living with HIV (PLWH), executive dysfunction is implicated in ProM impairments. However, specific subcomponents of executive functioning involved in ProM deficits remain poorly understood. Unlike more "traditional" neurocognitive (NC) measures of executive functioning associated with dorsolateral prefrontal cortex (i.e., conceptual reasoning, abstraction), those associated with medial orbitofrontal/ventromedial prefrontal (mOF/vmP) cortex (i.e., decision making, inhibitory control, goal-oriented behavior) have yet to be examined in ProM.METHOD: This study characterized ProM ability in a sample of 89 HIV-seropositive adults and examined the unique role of decision-making ability in ProM. Participants completed a standard NC battery, the Iowa Gambling Task (IGT; a decision-making measure), and the Memory for Intentions Screening Test (MIST; a ProM measure).RESULTS: Correlational analyses revealed that both traditional executive functioning measures and the IGT were associated with ProM. Regression analyses revealed that the IGT significantly predicted ProM, even after accounting for NC measures. Among all NC measures, only executive functioning significantly contributed to ProM.DISCUSSION: Further examination of mOF/vmP-sensitive executive dysfunction within this population is needed as PLWH may require more tailored treatment recommendations due to specific decision-making difficulties that can impact medication management. |
DOI | 10.1080/13803395.2014.935705 |
Alternate Journal | J Clin Exp Neuropsychol |
PubMed ID | 25089330 |
PubMed Central ID | PMC5584640 |
Grant List | R24 MH059724 / MH / NIMH NIH HHS / United States R24MH59724 / MH / NIMH NIH HHS / United States R25 MH080663 / MH / NIMH NIH HHS / United States K23MH07971801 / MH / NIMH NIH HHS / United States U01MH083501 / MH / NIMH NIH HHS / United States U01 MH083501 / MH / NIMH NIH HHS / United States N01MH22005 / MH / NIMH NIH HHS / United States K23 MH079718 / MH / NIMH NIH HHS / United States |