Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration.
Submitted by dcc on Wed, 07/01/2020 - 7:15pm
Title | Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Croteau, D, Best, BM, Letendre, S, Rossi, SS, Ellis, RJ, Clifford, DB, Collier, AC, Gelman, BB, McArthur, JC, McCutchan, JAllen, Morgello, S, Grant, I |
Corporate Authors | CHARTER Group |
Journal | AIDS |
Volume | 26 |
Issue | 7 |
Pagination | 890-3 |
Date Published | 2012 Apr 24 |
ISSN | 1473-5571 |
Keywords | Adult, CCR5 Receptor Antagonists, CHARTER, Chromatography, Reverse-Phase, Cross-Sectional Studies, Cyclohexanes, Female, HIV Infections, HIV-1, Humans, Inhibitory Concentration 50, Internal, Male, Maraviroc, Middle Aged, RNA, Viral, Tandem Mass Spectrometry, Triazoles |
Abstract | To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4 ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF. |
DOI | 10.1097/QAD.0b013e328351f627 |
Alternate Journal | AIDS |
PubMed ID | 22313954 |
PubMed Central ID | PMC3454507 |
Grant List | N01 MH022005 / MH / NIMH NIH HHS / United States N01MH22005 / MH / NIMH NIH HHS / United States U01 MH083506 / MH / NIMH NIH HHS / United States U01 MH83506 / MH / NIMH NIH HHS / United States |