Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.
Title | Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Fazeli, PL, Moore, DJ, Franklin, DR, Umlauf, A, Heaton, RK, Collier, AC, Marra, CM, Clifford, DB, Gelman, BB, Sacktor, NC, Morgello, S, Simpson, DM, McCutchan, JA, Grant, I, Letendre, SL |
Journal | Curr HIV Res |
Volume | 14 |
Issue | 4 |
Pagination | 324-30 |
Date Published | 2016 |
ISSN | 1873-4251 |
Keywords | Adult, AIDS Dementia Complex, Amyloid beta-Peptides, Cerebrospinal Fluid, Cross-Sectional Studies, Dementia, Female, HIV Infections, Humans, Male, Middle Aged |
Abstract | BACKGROUND: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients.OBJECTIVE: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).METHODS: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.RESULTS: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).CONCLUSION: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND. |
DOI | 10.2174/1570162x14666151221145926 |
Alternate Journal | Curr HIV Res |
PubMed ID | 26673902 |
PubMed Central ID | PMC4916008 |
Grant List | U24 MH100928 / MH / NIMH NIH HHS / United States R01 NR012907 / NR / NINR NIH HHS / United States R01 DA034497 / DA / NIDA NIH HHS / United States P30 MH062512 / MH / NIMH NIH HHS / United States U01 MH083506 / MH / NIMH NIH HHS / United States U10 NS077384 / NS / NINDS NIH HHS / United States R01 MH060720 / MH / NIMH NIH HHS / United States K99 AG048762 / AG / NIA NIH HHS / United States U01 AI035042 / AI / NIAID NIH HHS / United States R01 AG042165 / AG / NIA NIH HHS / United States R01 NS079166 / NS / NINDS NIH HHS / United States R03 DA022137 / DA / NIDA NIH HHS / United States R01 MH080150 / MH / NIMH NIH HHS / United States R01 AG034852 / AG / NIA NIH HHS / United States K24 MH097673 / MH / NIMH NIH HHS / United States P50 DA026306 / DA / NIDA NIH HHS / United States R01 MH078748 / MH / NIMH NIH HHS / United States HHSN271201000030C / MH / NIMH NIH HHS / United States P30 MH075673 / MH / NIMH NIH HHS / United States R01 MH092225 / MH / NIMH NIH HHS / United States U2G PS000623 / PS / NCHHSTP CDC HHS / United States UM1 AI069495 / AI / NIAID NIH HHS / United States R25 MH081482 / MH / NIMH NIH HHS / United States R21 MH100968 / MH / NIMH NIH HHS / United States R01 MH058076 / MH / NIMH NIH HHS / United States HHSN271201000036C / MH / NIMH NIH HHS / United States R01 MH078737 / MH / NIMH NIH HHS / United States R01 NS072005 / NS / NINDS NIH HHS / United States P01 DA026146 / DA / NIDA NIH HHS / United States UM1 AI035043 / AI / NIAID NIH HHS / United States R01 MH096648 / MH / NIMH NIH HHS / United States U01 AI069432 / AI / NIAID NIH HHS / United States L30 AG045921 / AG / NIA NIH HHS / United States R01 MH101017 / MH / NIMH NIH HHS / United States N01MH22005 / MH / NIMH NIH HHS / United States U13 MH081676 / MH / NIMH NIH HHS / United States U01 AI069495 / AI / NIAID NIH HHS / United States N01 MH022005 / MH / NIMH NIH HHS / United States K30 RR022681 / RR / NCRR NIH HHS / United States R01 MH083552 / MH / NIMH NIH HHS / United States R01 MH099987 / MH / NIMH NIH HHS / United States R01 MH107345 / MH / NIMH NIH HHS / United States R01 NS081196 / NS / NINDS NIH HHS / United States U24 MH100930 / MH / NIMH NIH HHS / United States R03 AG044910 / AG / NIA NIH HHS / United States R01 MH099733 / MH / NIMH NIH HHS / United States |