Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.

TitleLower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia.
Publication TypeJournal Article
Year of Publication2016
AuthorsFazeli, PL, Moore, DJ, Franklin, DR, Umlauf, A, Heaton, RK, Collier, AC, Marra, CM, Clifford, DB, Gelman, BB, Sacktor, NC, Morgello, S, Simpson, DM, McCutchan, JA, Grant, I, Letendre, SL
JournalCurr HIV Res
Volume14
Issue4
Pagination324-30
Date Published2016
ISSN1873-4251
KeywordsAdult, AIDS Dementia Complex, Amyloid beta-Peptides, Cerebrospinal Fluid, Cross-Sectional Studies, Dementia, Female, HIV Infections, Humans, Male, Middle Aged
Abstract

BACKGROUND: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients.OBJECTIVE: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND).METHODS: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used.RESULTS: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15).CONCLUSION: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

DOI10.2174/1570162x14666151221145926
Alternate JournalCurr HIV Res
PubMed ID26673902
PubMed Central IDPMC4916008
Grant ListU24 MH100928 / MH / NIMH NIH HHS / United States
R01 NR012907 / NR / NINR NIH HHS / United States
R01 DA034497 / DA / NIDA NIH HHS / United States
P30 MH062512 / MH / NIMH NIH HHS / United States
U01 MH083506 / MH / NIMH NIH HHS / United States
U10 NS077384 / NS / NINDS NIH HHS / United States
R01 MH060720 / MH / NIMH NIH HHS / United States
K99 AG048762 / AG / NIA NIH HHS / United States
U01 AI035042 / AI / NIAID NIH HHS / United States
R01 AG042165 / AG / NIA NIH HHS / United States
R01 NS079166 / NS / NINDS NIH HHS / United States
R03 DA022137 / DA / NIDA NIH HHS / United States
R01 MH080150 / MH / NIMH NIH HHS / United States
R01 AG034852 / AG / NIA NIH HHS / United States
K24 MH097673 / MH / NIMH NIH HHS / United States
P50 DA026306 / DA / NIDA NIH HHS / United States
R01 MH078748 / MH / NIMH NIH HHS / United States
HHSN271201000030C / MH / NIMH NIH HHS / United States
P30 MH075673 / MH / NIMH NIH HHS / United States
R01 MH092225 / MH / NIMH NIH HHS / United States
U2G PS000623 / PS / NCHHSTP CDC HHS / United States
UM1 AI069495 / AI / NIAID NIH HHS / United States
R25 MH081482 / MH / NIMH NIH HHS / United States
R21 MH100968 / MH / NIMH NIH HHS / United States
R01 MH058076 / MH / NIMH NIH HHS / United States
HHSN271201000036C / MH / NIMH NIH HHS / United States
R01 MH078737 / MH / NIMH NIH HHS / United States
R01 NS072005 / NS / NINDS NIH HHS / United States
P01 DA026146 / DA / NIDA NIH HHS / United States
UM1 AI035043 / AI / NIAID NIH HHS / United States
R01 MH096648 / MH / NIMH NIH HHS / United States
U01 AI069432 / AI / NIAID NIH HHS / United States
L30 AG045921 / AG / NIA NIH HHS / United States
R01 MH101017 / MH / NIMH NIH HHS / United States
N01MH22005 / MH / NIMH NIH HHS / United States
U13 MH081676 / MH / NIMH NIH HHS / United States
U01 AI069495 / AI / NIAID NIH HHS / United States
N01 MH022005 / MH / NIMH NIH HHS / United States
K30 RR022681 / RR / NCRR NIH HHS / United States
R01 MH083552 / MH / NIMH NIH HHS / United States
R01 MH099987 / MH / NIMH NIH HHS / United States
R01 MH107345 / MH / NIMH NIH HHS / United States
R01 NS081196 / NS / NINDS NIH HHS / United States
U24 MH100930 / MH / NIMH NIH HHS / United States
R03 AG044910 / AG / NIA NIH HHS / United States
R01 MH099733 / MH / NIMH NIH HHS / United States