HIV-1 Antigens in Neurons of Cocaine-Abusing Patients.
Submitted by dcc on Wed, 04/23/2014 - 7:47am
Title | HIV-1 Antigens in Neurons of Cocaine-Abusing Patients. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Fiala, M, Singer, EJ, Commins, D, Mirzaoiazova, T, Verin, A, Espinosa, A, Ugen, K, Bernas, M, Witte, M, Weinand, M, Lossinsky, AS |
Journal | Journal of Neurovirology |
Volume | 2 |
Start Page | 24 |
Pagination | 24-31 |
Date Published | 03/2008 |
Type of Article | Journal |
Other Numbers | PMCID: PMC2678818 |
Keywords | Blood-Brain Barrier, Cocaine, External, Extracellular signal-regulated kinase, HIV-1, HIV-1-associated dementia., intercellular junctions |
Abstract | Cocaine opens the blood-brain barrier by deregulating transcription of target genes. Here we show that cocaine at blood concentrations in drug abusers disrupts endothelial cell junctions in parallel with signaling by phosphorylation of extracellular signal-regulated kinase, myristoylated alanine-rich C kinase and myosin light chain. Cocaine effects may be important in vivo since the neurons of drug abusing patients with HIV-1 associated dementia displayed gp120, p24 and Nef. |
URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678818/ |