Histopathological Differences Between the Anterior and Posterior Brain Arteries as a Function of Aging.

TitleHistopathological Differences Between the Anterior and Posterior Brain Arteries as a Function of Aging.
Publication TypeJournal Article
Year of Publication2017
AuthorsRoth, W, Morgello, S, Goldman, JE, Mohr, JP, Elkind, MSV, Marshall, RS, Gutierrez, J
JournalStroke
Volume48
Issue3
Pagination638-644
Date Published2017 Mar
ISSN1524-4628
KeywordsAdult, Aged, Aged, 80 and over, Aging, Arteries, Autopsy, Brain, Female, Humans, Internal, Male, Middle Aged, Young Adult
Abstract

BACKGROUND AND PURPOSE: We tested the hypothesis that posterior brain arteries differ pathologically from anterior brain arteries and that this difference varies with age.METHODS: Brain large arteries from 194 autopsied individuals (mean age 56±17 years, 63% men, 25% nonwhite, 17% with brain infarcts) were analyzed to obtain the areas of arterial layers and lumen as well as the relative content of elastin, collagen, and amyloid. Visual rating was used to determine the prevalence of atheroma, calcification, vasa vasorum, pattern of intima thickening, and internal elastic lamina gaps. We used multilevel models adjusting for age, sex, ethnicity, vascular risk factors, artery type and location, and multiple comparisons.RESULTS: Of 1362 large artery segments, 5% had vasa vasorum, 5% had calcifications, 15% had concentric intimal thickening, and 11% had atheromas. Posterior brain arteries had thinner walls, less elastin, and more concentric intima thickening than anterior brain arteries. Compared to anterior brain arteries, the basilar artery had higher arterial area encircled by the internal elastic lamina, whereas the vertebral arteries had higher prevalence of elastin loss, concentric intima thickening, and nonatherosclerotic stenosis. In younger individuals, vertebral artery calcifications were more likely than calcification in anterior brain arteries, but this difference attenuated with age.CONCLUSIONS: Posterior brain arteries differ pathologically from anterior brain arteries in the degree of wall thickening, elastin loss, and concentric intimal thickening.

DOI10.1161/STROKEAHA.116.015630
Alternate JournalStroke
PubMed ID28196941
PubMed Central IDPMC5330785
Grant ListR01 MH064168 / MH / NIMH NIH HHS / United States
U24 MH100931 / MH / NIMH NIH HHS / United States
HHSN271201300028C / MH / NIMH NIH HHS / United States
P50 AG008702 / AG / NIA NIH HHS / United States
R25 MH080663 / MH / NIMH NIH HHS / United States
U01 MH083501 / MH / NIMH NIH HHS / United States