Health-related quality of life 'well-being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity.

TitleHealth-related quality of life 'well-being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity.
Publication TypeJournal Article
Year of Publication2012
AuthorsKeltner, JR, Vaida, F, Ellis, RJ, Moeller-Bertram, T, Fitzsimmons, C, Duarte, NA, Robinson-Papp, J, Dworkin, RH, Clifford, DB, McArthur, JC, Simpson, DM, Collier, AC, Marra, CM, J Atkinson, H, Grant, I
Corporate AuthorsCHARTER Group
JournalPsychosomatics
Volume53
Issue4
Pagination380-6
Date Published2012 Jul-Aug
ISSN1545-7206
KeywordsCHARTER, Chronic Pain, Cohort Studies, Cross-Sectional Studies, Depressive Disorder, Female, HIV Infections, Humans, Internal, Linear Models, Male, Middle Aged, Neuralgia, Pain Measurement, Psychiatric Status Rating Scales, Quality of Life, Severity of Illness Index, United States
Abstract

BACKGROUND: Despite modern antiretroviral treatment, HIV-associated distal neuropathic pain (DNP) remains one of the most prevalent and debilitating complications of HIV disease. Neuropathic pain is often accompanied by depressed mood, and both pain and depression have been associated with decreased health-related quality of life (HRQOL) well-being. The relative contribution of depression and pain to worse life quality has not been addressed, however, even though a better understanding might sharpen intervention strategies.METHODS: We used the Medical Outcomes Study HIV (MOS-HIV) Health Survey and the Beck depression inventory-II and linear regression models to investigate HRQOL well-being in HIV-infected patients with DNP (n = 397) participating in an observational cohort study at six U.S. sites (CNS HIV Antiretroviral Treatment Effects Research Study, CHARTER).RESULTS: For this sample of patients with HIV DNP, severity of depressed mood was more highly correlated with HRQOL well-being than was pain intensity.CONCLUSIONS: These results suggest that interventions to improve HRQOL well-being in individuals with HIV-associated DNP may need to address not only pain intensity but mood state as well.

DOI10.1016/j.psym.2012.05.002
Alternate JournalPsychosomatics
PubMed ID22748751
PubMed Central IDPMC3389373
Grant ListK23 NS066789 / NS / NINDS NIH HHS / United States
K23 NS079311 / NS / NINDS NIH HHS / United States
N01 MH022005 / MH / NIMH NIH HHS / United States
P50 DA026306 / DA / NIDA NIH HHS / United States