Concurrent classification accuracy of the HIV dementia scale for HIV-associated neurocognitive disorders in the CHARTER Cohort.

TitleConcurrent classification accuracy of the HIV dementia scale for HIV-associated neurocognitive disorders in the CHARTER Cohort.
Publication TypeJournal Article
Year of Publication2013
AuthorsSakamoto, M, Marcotte, TD, Umlauf, A, Franklin, D, Heaton, RK, Ellis, RJ, Letendre, S, Alexander, T, McCutchan, JA, Morgan, EE, Woods, SPaul, Collier, AC, Marra, CM, Clifford, DB, Gelman, B, McArthur, JC, Morgello, S, Simpson, DM, Grant, I
Corporate AuthorsCHARTER Group
JournalJ Acquir Immune Defic Syndr
Date Published2013 Jan 01
KeywordsAdult, AIDS Dementia Complex, CHARTER, Clinical Medicine, Female, Humans, Internal, Male, Middle Aged, Sensitivity and Specificity, Severity of Illness Index, United States

BACKGROUND: The HIV Dementia Scale (HDS) was developed to screen for HIV-associated neurocognitive disorders (HAND), but concerns have persisted regarding its substandard sensitivity. This study aimed to examine the classification accuracy of the HDS using raw and norm-based cut points and to evaluate the contribution of the HDS subtests to predicting HAND.METHODS: A total of 1580 HIV-infected participants from 6 US sites completed the HDS, and a gold standard neuropsychological battery, on which 51% of participants were impaired.RESULTS: Sensitivity and specificity to HAND using the standard raw HDS cut point were 24% and 92%, respectively. The raw HDS subtests of attention, recall, and psychomotor speed significantly contributed to classification of HAND, whereas visuomotor construction contributed the least. A modified raw cut point of 14 yielded sensitivity of 66% and specificity of 61%, with cross-validation. Using norms also significantly improved sensitivity to 69% with a concomitant reduction of specificity to 56%, whereas the positive predictive value declined from 75% to 62% and negative predictive value improved from 54% to 64%. The HDS showed similarly modest rates of sensitivity and specificity among subpopulations of individuals with minimal comorbidity and successful viral suppression.CONCLUSIONS: Findings indicate that while the HDS is a statistically significant predictor of HAND, particularly when adjusted for demographic factors, its relatively low diagnostic classification accuracy continues to hinder its clinical utility. A raw cut point of 14 greatly improved the sensitivity of the previously established raw cut score, but may be subject to ceiling effects, particularly on repeat assessments.

Alternate JournalJ. Acquir. Immune Defic. Syndr.
PubMed ID23111573
PubMed Central IDPMC3529802
Grant ListHHSN271201000030C / MH / NIMH NIH HHS / United States
HHSN271201000036C / MH / NIMH NIH HHS / United States
N01MH22005 / MH / NIMH NIH HHS / United States
UL1 RR029887 / RR / NCRR NIH HHS / United States
N01 MH022005 / MH / NIMH NIH HHS / United States