Axonal damage is a late component of vacuolar myelopathy

TitleAxonal damage is a late component of vacuolar myelopathy
Publication TypeJournal Article
Year of Publication2002
AuthorsRottnek, M, DiRocco, A, Laudier, D, Morgello, S
Date Published02/2002
Keywords80 and over, Aged, Amyloid beta-Protein Precursor, Antigens, CD, Differentiation, Internal, Myelomonocytic, Spinal Cord Diseases

The role of axonopathy in myelin disorders recently has been examined. To investigate axonal pathologic changes in vacuolar myelopathy (VM), semiquantitative immunohistochemical stains for inflammation, axonal damage, and gliosis were performed on spinal cord sections from patients with AIDS with and without VM and from HIV-negative controls. Significant axonal damage was present in only moderate to severe VM, despite inflammation at all stages. The authors conclude that axonal damage is not present in early disease; it is present in moderate to severe vacuolar myelopathy and may contribute to clinical deficits in late stages of this disorder.