β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.
Submitted by dcc on Tue, 11/21/2017 - 1:06pm
Title | β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Dever, SM, Rodriguez, M, El-Hage, N |
Journal | J Neurovirol |
Volume | 22 |
Issue | 6 |
Pagination | 866-870 |
Date Published | 2016 Dec |
ISSN | 1538-2443 |
Abstract | We previously reported that mRNA expression of the unique alternatively spliced OPRM1 isoform μ-opioid receptor-1K (MOR-1K), which exhibits excitatory cellular signaling, is elevated in HIV-infected individuals with combined neurocognitive impairment (NCI) and HIV encephalitis (HIVE). It has recently been shown that the β2-adrenergic receptor (β2-AR) chaperones MOR-1K, normally localized intracellularly, to the cell surface. Here, we found mRNA expression of the adrenoceptor beta 2 (ADRB2) gene is also elevated in NCI-HIVE individuals, as well as that β2-AR protein expression is elevated in HIV-1-infected primary human astrocytes treated with morphine, and discuss the implications for MOR-1K subcellular localization in this condition. |
DOI | 10.1007/s13365-016-0464-1 |
Alternate Journal | J. Neurovirol. |
PubMed ID | 27400929 |
PubMed Central ID | PMC5228594 |
Grant List | U24 MH100929 / MH / NIMH NIH HHS / United States U01 MH083507 / MH / NIMH NIH HHS / United States R24 MH059724 / MH / NIMH NIH HHS / United States U01 MH083500 / MH / NIMH NIH HHS / United States R21 DA041287 / DA / NIDA NIH HHS / United States R24 NS045491 / NS / NINDS NIH HHS / United States F32 DA033898 / DA / NIDA NIH HHS / United States R24 MH059745 / MH / NIMH NIH HHS / United States R24 NS038841 / NS / NINDS NIH HHS / United States N01 MH032002 / MH / NIMH NIH HHS / United States U01 MH083501 / MH / NIMH NIH HHS / United States U01 MH083545 / MH / NIMH NIH HHS / United States U01 MH083506 / MH / NIMH NIH HHS / United States R01 DA036154 / DA / NIDA NIH HHS / United States |