β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.

Titleβ-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.
Publication TypeJournal Article
Year of Publication2016
AuthorsDever, SM, Rodriguez, M, El-Hage, N
JournalJ Neurovirol
Volume22
Issue6
Pagination866-870
Date Published2016 Dec
ISSN1538-2443
Abstract

We previously reported that mRNA expression of the unique alternatively spliced OPRM1 isoform μ-opioid receptor-1K (MOR-1K), which exhibits excitatory cellular signaling, is elevated in HIV-infected individuals with combined neurocognitive impairment (NCI) and HIV encephalitis (HIVE). It has recently been shown that the β2-adrenergic receptor (β2-AR) chaperones MOR-1K, normally localized intracellularly, to the cell surface. Here, we found mRNA expression of the adrenoceptor beta 2 (ADRB2) gene is also elevated in NCI-HIVE individuals, as well as that β2-AR protein expression is elevated in HIV-1-infected primary human astrocytes treated with morphine, and discuss the implications for MOR-1K subcellular localization in this condition.

DOI10.1007/s13365-016-0464-1
Alternate JournalJ. Neurovirol.
PubMed ID27400929
PubMed Central IDPMC5228594
Grant ListU24 MH100929 / MH / NIMH NIH HHS / United States
U01 MH083507 / MH / NIMH NIH HHS / United States
R24 MH059724 / MH / NIMH NIH HHS / United States
U01 MH083500 / MH / NIMH NIH HHS / United States
R21 DA041287 / DA / NIDA NIH HHS / United States
R24 NS045491 / NS / NINDS NIH HHS / United States
F32 DA033898 / DA / NIDA NIH HHS / United States
R24 MH059745 / MH / NIMH NIH HHS / United States
R24 NS038841 / NS / NINDS NIH HHS / United States
N01 MH032002 / MH / NIMH NIH HHS / United States
U01 MH083501 / MH / NIMH NIH HHS / United States
U01 MH083545 / MH / NIMH NIH HHS / United States
U01 MH083506 / MH / NIMH NIH HHS / United States
R01 DA036154 / DA / NIDA NIH HHS / United States